Synthesis and Immunostimulating Properties of Novel Adamant-1-yl Tripeptides

Ribić, Rosana; Habjanec, Lidija; Vranešić, Branka; Frkanec, Ruža; Tomić, Srđanka

doi:10.1002/cbdv.201100232

Pregled bibliografske jedinice broj: 521321

Synthesis and Immunostimulating Properties of Novel Adamant-1-yl Tripeptides

Ribić, Rosana; Habjanec, Lidija; Vranešić, Branka; Frkanec, Ruža; Tomić, Srđanka

Synthesis and Immunostimulating Properties of Novel Adamant-1-yl Tripeptides // Chemistry & biodiversity, 9 (2012), 4; 777-788 doi:10.1002/cbdv.201100232 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 521321 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis and Immunostimulating Properties of Novel Adamant-1-yl Tripeptides

Autori
Ribić, Rosana ; Habjanec, Lidija ; Vranešić, Branka ; Frkanec, Ruža ; Tomić, Srđanka

Izvornik
Chemistry & biodiversity (1612-1872) 9 (2012), 4; 777-788

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adamant-1-yl tripeptides ; immunostimulating activity ; adamant-2-yl tripeptides ; peptidoglycan monomer

Sažetak
The aim of this work was to prepare L- and D- (adamant-1-yl)-Gly-L-Ala-D-isoGln peptides in order to study their adjuvant (immunostimulating) activity. Adjuvant activity of adamant-1-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D- MurNAc-L-Ala-D-isoGln-mesoDAP(εNH2)-D-Ala-D-Ala) and structurally related adamant-2-yl tripeptides.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Biotehnologija

POVEZANOST RADA

Projekti:
MZOS-021-0212432-2431 - Nove formulacije antigena i imunostimulatora - utjecaj na imunoreakciju (Frkanec, Ruža, MZOS ) ( CroRIS)
MZOS-119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Tomić-Pisarović, Srđanka, MZOS ) ( CroRIS)

Ustanove:
Imunološki zavod d.d.,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Branka Vranešić (autor)