Naslov
Worldwide spread of the TP53 gene polymorphisms Arg72Pro and intron 3 (+16bp)

Autori
Bišof, Vesna ; Peričić Salihović, Marijana ; Smolej Narančić, Nina ; Škarić-Jurić, Tatjana ; Janićijević, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Final program and abstracts of the 7th ISABS conference in forensic, anthropological and medical genetics and Mayo clinic lectures in translational medicine / Schanfield, Moses ; Primorac, Dragan ; Vuk-Pavlović, Stanimir - Zagreb : International Society for Applied Biological Sciences (ISABS), 2011, 279-279

Skup
Peti hrvatski kongres iz humane genetike

Mjesto i datum
Bol, Hrvatska, 20.06.2011. - 21.06.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
p53; polymorphism; Arg72Pro; world gradient; Croatia

Sažetak
Aim: To compare the allele frequencies of two polymorphisms in Croatian population with data for other populations worldwide. The TP53 gene is called “genome keeper” due to its activation in case of DNA damage causing the cell cycle arrest enabling thus the DNA repair, or activating the mechanisms of apoptosis. The polymorphisms Arg72Pro and intron 3 (+16bp) studied here have been suggested to be associated with various diseases being therefore interesting in the population context as well. Method: Frequencies of studied alleles were compared using the population differentiation test. The data were obtained by searching the Medline. Results: The frequency of the Arg allele in Croatian population was 75.9%, while the frequency of the A1 allele was 85.7%. The frequency of the Arg allele was similar to the frequencies of Portuguese (77.2%), Hungarians (77.7%), Russians (75.4%) and Yakuts (75.6%). The biggest difference in Arg frequencies from the Croatian population was obtained for Nigerians (37%) and Australian Aborigines (45%). The frequency of the A1 allele in Croatian population was similar to frequencies in other European populations (83-88%), Indian (83%) and Turkish population (86%) while the most pronounced difference emerged with the South African population. Conclusion: The worldwide frequency gradient of the Pro allele on codon 72 as well as of the A2 allele in intron 3 of the TP53 gene was found to spread from north to south. The allele frequencies in Croatian population were in concordance with the available data for other European populations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA