Naslov
Distinct MHC class I–dependent NK cell– activating receptors control cytomegalovirus infection in different mouse strains

Autori
Pyzik, Michael ; Charbonneau, Benoit ; Gendron-Pontbriand, Eve-Marie ; Babić, Marina ; Krmpotić, Astrid ; Jonjić, Stipan ; Vidal, Silvia

Izvornik
The Journal of experimental medicine (0022-1007) 208 (2011), 5; 1105-1117

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NK cells; cytomegalovirus; MHC Class I

Sažetak
Recognition of mouse cytomegalovirus (MCMV)–infected cells by activating NK cell receptors was first described in the context of Ly49H, which confers resistance to C57BL/6 mice. We investigated the ability of other activating Ly49 receptors to recognize MCMV-infected cells in mice from various H-2 backgrounds. We observed that Ly49P1 from NOD/Ltj mice, Ly49L from BALB mice, and Ly49D2 from PWK/Pas mice respond to MCMV-infected cells in the context of H-2Dk and the viral protein m04/gp34. Recognition was also seen in the H-2d and/or H-2f contexts, depending on the Ly49 receptor examined, but never in H-2b. Furthermore, BALB.K (H-2k) mice showed reduced viral loads compared with their H-2d or H-2b congenic partners, a reduction which was dependent on interferon γ secretion by Ly49L+ NK cells early after infection. Adoptive transfer of Ly49L+, but not Ly49L−, NK cells significantly increased resistance against MCMV infection in neonate BALB.K mice. These results suggest that multiple activating Ly49 receptors participate in H-2–dependent recognition of MCMV infection, providing a common mechanism of NK cell–mediated resistance against viral infection.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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