Naslov
VLA-4 retargeted adenovirus type 5 as vector for acute myeloid leukemia

Autori
Majhen, Dragomira ; Jelušić, Tihana ; Gabrilovac, Jelka ; Ambriović-Ristov, Andreja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Targeting and Imaging of tumor microenvironment. Book of Abstracts. / - , 2009

Skup
Targeting and Imaging of tumor microenvironment

Mjesto i datum
Ile Berder, Francuska, 23.09.2009. - 26.09.2009

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
adenovirus; VLA-4; retargeting

Sažetak
Acute myeloid leukemia (AML) is a cancer of the myeloid line of white blood cells, characterized by the rapid proliferation of abnormal cells which accumulate in the bone marrow and interfere with the production of normal blood cells. AML is the most common acute leukemia affecting adults, and its incidence increases with age. The basic therapeutic approach to patients with AML aged 18-60 years has changed little over the last 3 decades and classically involves chemotherapy treatment which is very invasive and elderly patient poorly tolerate its toxicity. Since less than 40% of AML patients under age of 60 can be cured, and in older adults, accounting for the majority of AML patients, long-term disease-free survival rate is rare with limited available treatment options, there is urgent need for the development of novel targeted therapies for AML. Gene therapy, with emphasis on receptor targeted gene delivery, might be a future option in treating AML.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA