Naslov
Synthesis and Biological Evaluation of New Mannose Derived Immunomodulating Adamantyltripeptides

Autori
Ribić, Rosana ; Habjanec, Lidija ; Vranešić, Branka ; Frkanec, Ruža ; Tomić, Srđanka

Izvornik
Croatica chemica acta (0011-1643) 84 (2011), 2; 233-244

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
O-mannopyranosides; adamantyltripeptides; peptidoglycan monomer; immunomodulation

Sažetak
A novel class of mannosylated adamantyltripeptides, general formula of which is α-Man-OCH2CH(CH3)CO-AdGly-L-Ala-D-isoGln, were prepared, characterized, and their possible immunomodulatory properties investigated in some preliminary tests in vivo. All newly synthesized glycopeptides comprise in their structure the adamantylglycyl moiety linked to the dipeptide L-Ala-D-isoGln, as well as mannose. Adjuvant activity of mannosylated adamant-2-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH2)-D-Ala-D-Ala).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA