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Pregled bibliografske jedinice broj: 515513

Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones

Fajdetić, Andreja; Vinter, Adrijana; Čipčić Paljetak, Hana; Padovan, Jasna; Palej Jakopović, Ivana; Kapić, Samra; Alihodžić, Sulejman; Filić, Darko; Modrić, Marina; Košutić-Hulita, Nada et al.
Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones // European Journal of Medicinal Chemistry, 46 (2011), 8; 3388-3397 doi:10.1016/j.ejmech.2011.05.002 (međunarodna recenzija, članak, znanstveni)

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Naslov
Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones

Autori
Fajdetić, Andreja ; Vinter, Adrijana ; Čipčić Paljetak, Hana ; Padovan, Jasna ; Palej Jakopović, Ivana ; Kapić, Samra ; Alihodžić, Sulejman ; Filić, Darko ; Modrić, Marina ; Košutić-Hulita, Nada ; Antolović, Roberto ; Ivezić Schoenfeld, Zrinka ; Mutak, Stjepan ; Eraković Haber, Vesna ; Spaventi, Radan

Izvornik
European Journal of Medicinal Chemistry (0223-5234) 46 (2011), 8; 3388-3397

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
makrolide; resistance; antibacterial activity; pharmacokinetics; oral bioavailability

Sažetak
Synthesis, antibacterial activity and pharmacokinetic properties of a novel class of macrolide antibioticsdmacrolonesdderived from azithromycin, comprising oxygen atom(s) in the linker and either free or esterified quinolone 3-carboxylic group, are reported. Selected compounds showed excellent antibacterial potency towards key erythromycin resistant respiratory pathogens. However, the majority of compounds lacked good bioavailability. The isopropyl ester, compound 35, and a macrolone derivative with an elongated linker 29 showed the best oral bioavailability in rats, both accompanied with an excellent overall microbiology profile addressing inducible and constitutive MLSb as well as efflux mediated macrolide resistance in streptococci, while compound 29 is more potent against staphylococci.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Fidelta d.o.o.

Profili:

Avatar Url Ivana Palej Jakopović (autor)

Avatar Url Marina Modrić (autor)

Avatar Url Vesna Eraković Haber (autor)

Avatar Url Sulejman Alihodžić (autor)

Avatar Url Jasna Padovan (autor)

Avatar Url Zrinka Ivezić (autor)

Avatar Url Nada Košutić-Hulita (autor)

Avatar Url Hana Čipčić Paljetak (autor)

Avatar Url Samra Kapić (autor)

Avatar Url Andreja Fajdetić (autor)

Avatar Url Darko Filić (autor)

Avatar Url Stjepan Mutak (autor)

Avatar Url Radan Spaventi (autor)

Avatar Url Roberto Antolović (autor)

Avatar Url Adrijana Vinter (autor)

Poveznice na cjeloviti tekst rada:

doi ac.els-cdn.com www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Fajdetić, Andreja; Vinter, Adrijana; Čipčić Paljetak, Hana; Padovan, Jasna; Palej Jakopović, Ivana; Kapić, Samra; Alihodžić, Sulejman; Filić, Darko; Modrić, Marina; Košutić-Hulita, Nada et al.
Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones // European Journal of Medicinal Chemistry, 46 (2011), 8; 3388-3397 doi:10.1016/j.ejmech.2011.05.002 (međunarodna recenzija, članak, znanstveni)
Fajdetić, A., Vinter, A., Čipčić Paljetak, H., Padovan, J., Palej Jakopović, I., Kapić, S., Alihodžić, S., Filić, D., Modrić, M. & Košutić-Hulita, N. (2011) Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones. European Journal of Medicinal Chemistry, 46 (8), 3388-3397 doi:10.1016/j.ejmech.2011.05.002.
@article{article, author = {Fajdeti\'{c}, Andreja and Vinter, Adrijana and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Padovan, Jasna and Palej Jakopovi\'{c}, Ivana and Kapi\'{c}, Samra and Alihod\v{z}i\'{c}, Sulejman and Fili\'{c}, Darko and Modri\'{c}, Marina and Ko\v{s}uti\'{c}-Hulita, Nada and Antolovi\'{c}, Roberto and Ivezi\'{c} Schoenfeld, Zrinka and Mutak, Stjepan and Erakovi\'{c} Haber, Vesna and Spaventi, Radan}, year = {2011}, pages = {3388-3397}, DOI = {10.1016/j.ejmech.2011.05.002}, keywords = {makrolide, resistance, antibacterial activity, pharmacokinetics, oral bioavailability}, journal = {European Journal of Medicinal Chemistry}, doi = {10.1016/j.ejmech.2011.05.002}, volume = {46}, number = {8}, issn = {0223-5234}, title = {Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones}, keyword = {makrolide, resistance, antibacterial activity, pharmacokinetics, oral bioavailability} }
@article{article, author = {Fajdeti\'{c}, Andreja and Vinter, Adrijana and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Padovan, Jasna and Palej Jakopovi\'{c}, Ivana and Kapi\'{c}, Samra and Alihod\v{z}i\'{c}, Sulejman and Fili\'{c}, Darko and Modri\'{c}, Marina and Ko\v{s}uti\'{c}-Hulita, Nada and Antolovi\'{c}, Roberto and Ivezi\'{c} Schoenfeld, Zrinka and Mutak, Stjepan and Erakovi\'{c} Haber, Vesna and Spaventi, Radan}, year = {2011}, pages = {3388-3397}, DOI = {10.1016/j.ejmech.2011.05.002}, keywords = {makrolide, resistance, antibacterial activity, pharmacokinetics, oral bioavailability}, journal = {European Journal of Medicinal Chemistry}, doi = {10.1016/j.ejmech.2011.05.002}, volume = {46}, number = {8}, issn = {0223-5234}, title = {Synthesis, activity and pharmacokinetics of novel antibacterial 15-membered ring macrolones}, keyword = {makrolide, resistance, antibacterial activity, pharmacokinetics, oral bioavailability} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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