Naslov
Our investigations in the field of psoriasis immunopathogenesis

Autori
Prpić Massari, Larisa ; Kaštelan, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
4th Congress of Croatian Dermatovenereologists with International Participation - Abstract Book / - , 2011

Skup
4. Kongres hrvatskih dermatovenerologa s međunarodnim sudjelovanjem

Mjesto i datum
Osijek, Hrvatska, 05.05.2011. - 08.05.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Psoriasis; Imunnopathogenesis; Perforin

Sažetak
Psoriasis is a chronic inflammatory immune-mediated disease characterized by hyperproliferation and aberrant differentiation of keratinocytes. It is also a complex genetic disorder influenced by multiple genes identified at different chromosomal loci. In a genetically predisposed individual, psoriasis seems to develop as a result of the interplay between cells and mediators of the innate and adaptive immune system. Further on, we shall highlight our 10-years investigation in the field of psoriasis immunogenetics particularly the role of HLA susceptibility genes as well as the significance of different cytolytic mechanisms in the immunopathogenesis of psoriasis.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA