Naslov
Angiotensin-converting enzyme deletion allele is beneficial for the longevity of Europeans

Autori
Zajc Petranović, Matea ; Škarić-Jurić, Tatjana ; Smolej Narančić, Nina ; Tomas, Željka ; Krajačić, Petra ; Miličić, Jasna ; Barbalić, Maja ; Tomek-Roksandić, Spomenka

Izvornik
Age (0161-9152) 34 (2012), 3; 583-595

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
aged; aged 80 and over; longevity; ACE I/D polymorphism; hypertension; meta-analysis

Sažetak
The human angiotensin converting enzyme gene (ACE) is one of the most investigated candidate genes for cardiovascular diseases (CVD) but the understanding of its role among the elderly is vague. Therefore, this study focuses at: a) testing the association of ACE polymorphism with CVD risk factors among the elderly, and b) detecting the possible unequal distribution of ACE genotypes between senescent and younger segments of the European populations. The association of ACE I/D polymorphism with CVD health status (hypertension, obesity, dislypidemia) in 301 very old subjects (88.2±5 yrs ; F/M=221/80) was tested by means of logistic regression analysis. The meta-analysis of D allele frequency in general vs. elderly (80+ yrs) groups was conduced using all publicly available data for European populations comprising both age cohorts. Multiple multinomial logistic regression revealed that within this elderly sample, age (younger olds, 80–90 yrs), female sex (OR=3.13, 95%CI=1.59-6.19) and elevated triglycerides (OR=2.53, 95%CI=1.29–4.95) were positively associated with hypertension, while ACE polymorphism was not. It was also established that the DD genotype was twice as high in 80+ cohort compared to general population of Croatia (p<0.00001). This trend was confirmed by the meta- analysis that showed higher D allele frequencies in olds from nine of ten considered European populations (OR=1.19, 95%CI=1.08-1.31). The data in elderly cohort do not confirm previously reported role of ACE DD genotype to the development of hypertension. Moreover, meta-analysis indicated that ACE D allele has some selective advantage that contributes to longevity in majority of European populations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA