Naslov
EFFECTS OF PPARγ, APOE, ACE AND AT1R GENE VARIANTS ON DEVELOPMENT OF METABOLIC SYNDROME

Autori
Božina, Tamara ; Sertić, Jadranka ; Ljubić, Hana ; Jelaković, Bojan ; Božina, Nada ; Lovrić, Jasna ; Karanović, Sandra ; Reiner, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 21st International Congress of Clinical Chemistry and Laboratory Medicine. U:Clin Chem Lab Med 2011 ; 49, Special Suppl, pp S1-S874 / Plebani, Mario - Berlin : Walter de Gruyter, 2011, S351-S351

Skup
21st International Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Berlin, Njemačka, 15.05.2011. - 19.05.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
metabolic syndrome; PPARG; ApoE; ACE; AT1R

Sažetak
Background. Metabolic syndrome (MS) is a cluster of risk factors including hypertension, abdominal obesity, dyslipidemia and hyperglycemia. The contribution of genetic factors to the development of MS has been widely recognized, but the contribution of the genes has not yet been fully clarified. We investigated the possible role of gene polymorphisms of PPAR (Pro12Ala), ApoE, ACE (I/D) and AT1R (1166A>C) in MS. Methods. Genotyping of PPARG2, AT1R and ACE was performed by PCR-RFLP, APOE by real-time PCR in group of 281 patients and 119 controls. Associations of alleles and genotypes with biological and clinical variables were performed using UNPHASED-3.0.10. Results. In comparison to females, males were older, had higher BMI and waist circumference, higher triglycerides and glucose levels and lower HDL. Males had significantly more often high blood pressure. Age accounted for the differences in glucose levels and HDL. We found significant association of AT1R variants and the developement of MS (p=0.03), with the C allele being associated with lower risk. We found association of waist circumference with: ACE variants (p=0.03), with D allele carrying the higher risk ; AT1R with A as the risk allele (p=0.05). APOE4 variant was associated with the waist circumference (p=0.05) and the levels of HDL (p=0.03), and ACE genotype was associated with glucose levels (p=0.02), with II genotype carrying the lowest risk. Conclusion. Gene variants of AT1R, ACE and ApoE could be susceptibility factors of obesity, glucose intolerance and lipid status contributing to the development of metabolic syndrome.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA