Expression of TWEAK in normal human skin, dermatitis and epidermal neoplasms : association with proliferation and differentiation of keratinocytes

Peternel, Sandra; Manestar-Blažić, Teo; Brajac, Ines; Prpić Massari, Larisa; Kaštelan, Marija

doi:10.1111/j.1600-0560.2011.01762.x

Pregled bibliografske jedinice broj: 512924

Expression of TWEAK in normal human skin, dermatitis and epidermal neoplasms : association with proliferation and differentiation of keratinocytes

Peternel, Sandra; Manestar-Blažić, Teo; Brajac, Ines; Prpić Massari, Larisa; Kaštelan, Marija

Expression of TWEAK in normal human skin, dermatitis and epidermal neoplasms : association with proliferation and differentiation of keratinocytes // Journal of cutaneous pathology, 38 (2011), 10; 780-789 doi:10.1111/j.1600-0560.2011.01762.x (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 512924 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Expression of TWEAK in normal human skin, dermatitis and epidermal neoplasms : association with proliferation and differentiation of keratinocytes

Autori
Peternel, Sandra ; Manestar-Blažić, Teo ; Brajac, Ines ; Prpić Massari, Larisa ; Kaštelan, Marija

Izvornik
Journal of cutaneous pathology (0303-6987) 38 (2011), 10; 780-789

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
discoid lupus erythematosus; lichen planus; psoriasis; skin cancer; tumor necrosis factor-like weak inducer of apoptosis; TWEAK

Sažetak
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) has been implicated in the pathogenesis of various inflammatory pathologies and cancer. We aimed to investigate its expression in normal human skin, inflammatory skin diseases and epidermal neoplasms. Immunohistochemistry for TWEAK was performed in samples of healthy skin, plaque psoriasis, lichen planus, prurigo nodularis, discoid lupus erythematosus, lichen sclerosus, seborrheic keratosis, common warts, actinic keratosis, Bowen's disease, keratoacanthoma and basal and squamous cell carcinoma. Double immunofluorescence was used to investigate co-localization of TWEAK with cytokeratin-10 and proliferating cell nuclear antigen (PCNA). TWEAK was robustly expressed in the epidermis of healthy skin and decreased in inflammatory conditions, both in the context of epidermal hyperplasia and atrophy. Decreased TWEAK immunoreactivity was regularly observed in common warts, actinic keratosis and Bowen's disease, particularly in areas of marked proliferation as evidenced by PCNA-positive nuclei. In squamous cell carcinoma, expression of TWEAK ranged from strong to completely absent, and it mostly corresponded with the expression of cytokeratin-10. TWEAK was absent in keratoacanthoma and basal cell carcinoma. TWEAK is a constitutively expressed epidermal protein whose downregulation might be an early indicator of disturbed differentiation or pathologic proliferation of keratinocytes that accompany inflammatory and neoplastic skin diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
062-0620239-0197 - Imunološki mehanizmi u patogenezi psorijaze (Kaštelan, Marija, MZOS ) ( CroRIS)
062-0620239-0199 - Uloga neurogene upale i psihičkih čimbenika u patogenezi psorijaze (Brajac, Ines, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Profili:

Larisa Prpić Massari (autor)