Naslov
Sinteza sulfonamido derivata nukleo baza
(Synthesis of sulfonamido nucleo base derivatives)

Autori
Ismaili, Hamit ; Hoti, Ramiz ; Žinić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts, XXII. Hrvatski skup kemičara i kemijskih inženjera / Tomašić, Vesna ; Maduna Valkaj, Karolina - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2011, 221-221

ISBN
978-953-6894-42-0

Skup
XXII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 13.02.2011. - 16.02.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
sulfonamido derivati nukleo baza
(sulfonamido nucleo base derivatives)

Sažetak
Sulfonamides represent an important class of medicinally important molecules and are known to possess wide varieties of biological activities which include antimicrobial drugs, carbonic anhydrase inhibitors, antithyroid agents, antitumour drugs, etc. [1]. Recently, we have prepared a series of novel N-1sulfonyl pyrimidine derivatives which exhibit strong antitumor activity [2]. As a part of our program directed toward the synthesis and characterization of biologically active nucleobase derivatives, we decided to synthesized sulfonamido derivatives of pyrimidine and purine nucleo bases. The sulfonylation of amines with sulfonyl chlorides in the presence of a base is still being used as the method of choice because of high efficiency and simplicity of the reaction. The series of 5-sulfonamido pyrimidines were prepared by heating 5-amninouracil with the selected sulfonylchlorides in pyridine. The reaction was regioselective and only isolated products were the C-5 substituted pyrimidines. On the other hand, the reaction of guanine or adenine bases with the one equivalent of sylfonylchloride in pyridine afforded 9-N-sulfonyl derivatives. Synthesis of the sulfonamido purine derivatives will be discussed. The structure of all compounds was confirmed by UV, IR, NMR spectra and elemental analysis. These products are under investigation for biological activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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