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Pregled bibliografske jedinice broj: 509150

The TP53 gene polymorphisms and survival of sporadic breast cancer patients

Bišof, Vesna; Peričić Salihović, Marijana; Smolej Narančić, Nina; Škarić-Jurić, Tatjana; Jakić-Razumović, Jasminka; Janićijević, Branka; Rudan, Pavao
The TP53 gene polymorphisms and survival of sporadic breast cancer patients // Medical oncology, 29 (2012), 2; 472-478 doi:10.1007/s12032-011-9875-2 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 509150 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The TP53 gene polymorphisms and survival of sporadic breast cancer patients

Autori
Bišof, Vesna ; Peričić Salihović, Marijana ; Smolej Narančić, Nina ; Škarić-Jurić, Tatjana ; Jakić-Razumović, Jasminka ; Janićijević, Branka ; Rudan, Pavao

Izvornik
Medical oncology (1357-0560) 29 (2012), 2; 472-478

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
breast cancer; survival; polymorphisms; TP53 gene; chemotherapy

Sažetak
The TP53 gene polymorphisms, Arg72Pro and PIN3 (+16 bp), can have prognostic and predictive value in different cancers including breast cancer. The aim of the present study is to investigate a potential association between different genotypes of these polymorphisms and clinicopathological variables with survival of breast cancer patients in Croatian population. Ninety-four women with sporadic breast cancer were retrospectively analyzed. Median follow-up period was 67.9 months. The effects of basic clinical and histopathological characteristics of tumor on survival were tested by Cox's proportional hazards regression analysis. The TNM stage was associated with overall survival by Kaplan-Meier analysis, univariate, and multivariate Cox's proportional hazards regression analysis, while grade was associated with survival by Kaplan-Meier analysis and univariate Cox's proportional hazards regression analysis. Different genotypes of the Arg72Pro and PIN3 (+16 bp) polymorphisms had no significant impact on survival in breast cancer patients. However, in subgroup of patients treated with chemotherapy without anthracycline, the A2A2 genotype of the PIN3 (+16 bp) polymorphism was associated with poorer overall survival than other genotypes by Kaplan-Meier analysis (P = 0.048). The TP53 polymorphisms, Arg72Pro and PIN3 (+16 bp), had no impact on survival in unselected sporadic breast cancer patients in Croatian population. However, the results support the role of the A2A2 genotype of the PIN3 (+16 bp) polymorphism as a marker for identification of patients that may benefit from anthracycline-containing chemotherapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija



POVEZANOST RADA

Projekti:
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Smolej-Narančić, Nina, MZOS ) ( CroRIS)
196-1962766-2751 - Populacijska struktura Hrvatske - antropogenetički pristup (Rudan, Pavao, MZOS ) ( CroRIS)
196-1962766-2763 - Molekularno-genetička obilježja populacija utemeljitelja - Romi kao model (Janićijević, Branka, MZOS ) ( CroRIS)

Ustanove:
Institut za antropologiju,
Klinički bolnički centar Zagreb

Profili:

Avatar Url Vesna Bišof (autor)

Avatar Url Jasminka Jakić-Razumović (autor)

Avatar Url Nina Smolej-Narančić (autor)

Avatar Url Marijana Peričić Salihović (autor)

Avatar Url Tatjana Škarić-Jurić (autor)

Avatar Url Branka Janićijević (autor)

Avatar Url Pavao Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi www.springerlink.com

Citiraj ovu publikaciju:

Bišof, Vesna; Peričić Salihović, Marijana; Smolej Narančić, Nina; Škarić-Jurić, Tatjana; Jakić-Razumović, Jasminka; Janićijević, Branka; Rudan, Pavao
The TP53 gene polymorphisms and survival of sporadic breast cancer patients // Medical oncology, 29 (2012), 2; 472-478 doi:10.1007/s12032-011-9875-2 (međunarodna recenzija, članak, znanstveni)
Bišof, V., Peričić Salihović, M., Smolej Narančić, N., Škarić-Jurić, T., Jakić-Razumović, J., Janićijević, B. & Rudan, P. (2012) The TP53 gene polymorphisms and survival of sporadic breast cancer patients. Medical oncology, 29 (2), 472-478 doi:10.1007/s12032-011-9875-2.
@article{article, author = {Bi\v{s}of, Vesna and Peri\v{c}i\'{c} Salihovi\'{c}, Marijana and Smolej Naran\v{c}i\'{c}, Nina and \v{S}kari\'{c}-Juri\'{c}, Tatjana and Jaki\'{c}-Razumovi\'{c}, Jasminka and Jani\'{c}ijevi\'{c}, Branka and Rudan, Pavao}, year = {2012}, pages = {472-478}, DOI = {10.1007/s12032-011-9875-2}, keywords = {breast cancer, survival, polymorphisms, TP53 gene, chemotherapy}, journal = {Medical oncology}, doi = {10.1007/s12032-011-9875-2}, volume = {29}, number = {2}, issn = {1357-0560}, title = {The TP53 gene polymorphisms and survival of sporadic breast cancer patients}, keyword = {breast cancer, survival, polymorphisms, TP53 gene, chemotherapy} }
@article{article, author = {Bi\v{s}of, Vesna and Peri\v{c}i\'{c} Salihovi\'{c}, Marijana and Smolej Naran\v{c}i\'{c}, Nina and \v{S}kari\'{c}-Juri\'{c}, Tatjana and Jaki\'{c}-Razumovi\'{c}, Jasminka and Jani\'{c}ijevi\'{c}, Branka and Rudan, Pavao}, year = {2012}, pages = {472-478}, DOI = {10.1007/s12032-011-9875-2}, keywords = {breast cancer, survival, polymorphisms, TP53 gene, chemotherapy}, journal = {Medical oncology}, doi = {10.1007/s12032-011-9875-2}, volume = {29}, number = {2}, issn = {1357-0560}, title = {The TP53 gene polymorphisms and survival of sporadic breast cancer patients}, keyword = {breast cancer, survival, polymorphisms, TP53 gene, chemotherapy} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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