Pregled bibliografske jedinice broj: 508005
Antitumor effect of Croatian propolis as a consequence of diverse sex-related dihydropyrimidine dehydrogenase (DPD) protein expression
Antitumor effect of Croatian propolis as a consequence of diverse sex-related dihydropyrimidine dehydrogenase (DPD) protein expression // Phytomedicine, 18 (2011), 852-858 doi:10.1016/j.phymed.2011.01.015 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 508005 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Antitumor effect of Croatian propolis as a consequence of diverse sex-related dihydropyrimidine dehydrogenase (DPD) protein expression
Autori
Sobočanec, Sandra ; Balog, Tihomir ; Šariċ, Ana ; Mačak-Šafranko, Željka ; Štroser, Marina ; Žarković, Kamelija ; Žarković, Neven ; Stojković, Ranko ; Ivanković, Siniša ; Marotti, Tatjana
Izvornik
Phytomedicine (0944-7113) 18
(2011);
852-858
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
propolis ; mammary carcinoma ; DPD ; tumor growth ; metastasis ; gender-related
Sažetak
The aim of this study was to detect the antitumor properties of Croatian propolis in BALB/c male and female mice injected with 4T1 mammary carcinoma. Furthermore, the gender- dependence of this effect and the possible involvement of combined effect of propolis and 5-Fluorouracil (5FU) on dihydropyrimidine dehydrogenase (DPD) transcriptional and translational level, were determined. In combination with 5FU propolis treatment induced gender-related effects. The results of the study revealed that pretreatment of mice with propolis combined with 5FU treatment prolonged the suppressive effect of 5FU on tumor growth and reduced the number of metastasis only in male mice. Only males pretreated with propolis prior to 5FU administration had decreased DPD protein level indicating higher sensitivity to 5FU. Thus, benefitial effects of propolis in male tumor-bearing mice treated with 5FU might be explained by increased sensitivity to 5FU as the result of translationally downregulated DPD.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti, Veterinarska medicina
POVEZANOST RADA
Projekti:
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Balog, Tihomir, MZOS ) ( CroRIS)
098-0982464-2390 - Novi terapijski modaliteti u liječenju malignih bolesti (Stojković, Ranko, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb
Profili:
Ranko Stojković
(autor)
Sandra Sobočanec
(autor)
Kamelija Žarković
(autor)
Neven Žarković
(autor)
Željka Mačak Šafranko
(autor)
Tihomir Balog
(autor)
Tatjana Marotti
(autor)
Siniša Ivanković
(autor)
Marina Cindrić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- BIOSIS Previews (Biological Abstracts)