Naslov
Bio-inspirirani gelatori. Sinteza i samo-udruživanje peptidnih gelatora s KLVFF fragmentom amiloidnog Aβ-proteina
(Bio-inspired gelators. Synthesis and self-assembly of peptidic gelators containing KLVFF sequence of the amyloid Aβ- protein.)

Autori
Čaplar, Vesna ; Frkanec, Leo ; Žinić Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / Tomašić, Vesna ; Maduna Valkaj, Karolina - Zagreb, 2011

Skup
XXII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 13.02.2011. - 16.02.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Bio-inspirirani gelatori; samo-udruživanje; amiloidni Aβ-protein
(Bio-inspired gelators; self-assembly; amyloid Aβ- protein)

Sažetak
The amyloid fibrils self-assembled from Aβ-protein are considered the most responsible for the formation of senile plaques of Alzheimer's disease. The KLVFF sequence of Aβ-protein seems to be the most important for its self-assembly into fibrous amyloidal aggregates and some short peptides containing the same sequence were also shown to bind to the amyloids. [1, 2]. A series of KLVFF containing peptidomimetics substituted at N and C termini with alkyl chains of various lengths were synthesized and tested for gelation of water and DMSO/water mixtures. The results of spectroscopic (1H-NMR, FTIR), morphology (TEM) and X-ray diffraction studies of formed gels revealed formation of fibrous aggregates with 8-10 nm diameters (diameter of Aβ-fibrils 10 nm) stabilized by β-sheet type hydrogen-bonding between KLVFF fragments. An artificial β-breaker molecule was designed by molecular modeling and shown to prevent efficiently aggregation of KLVFF-gelators and formation of the gels.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA