Naslov
Linear and bent halogen-bonded architectures in cocrystals: Design, properties and mechanism of formation via grinding

Autori
Friščić, Tomislav ; Cinčić, Dominik ; Jones, William

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
The 235th ACS National Meeting

Mjesto i datum
New Orleans (LA), Sjedinjene Američke Države, 06.04.2008. - 10.04.2008

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
halogen-bonded cocrystalls; solid-state grinding; mechanochemical methods

Sažetak
Multi-component molecular crystals (cocrystals) have recently been recognized suitable for the construction of functional solids, in particular pharmaceutical, electronic or optical materials, and have been utilized as tailor-made media for organic solid-state reactions. Such interest has inspired the exploration of new approaches for cocrystal synthesis and design. This contribution will delineate our experiences in using environmentally friendly mechanochemical methods (neat and liquid-assisted grinding) to construct halogen-bonded cocrystals. The halogen bond is becoming recognized as a viable alternative to the hydrogen bond in cocrystal design, and we present linear and zigzag halogen-bonded architectures constructed by solid-state grinding. We describe how solid-state properties of cocrystals can be controlled through manipulating the halogen bond strength, and provide a mechanism for mechanochemical cocrystal synthesis. The stepwise mechanism involves finite molecular assemblies as intermediates in the construction of halogen- bonded chains and results from the competition between strong (N...I) and weak (S...I) intermolecular interactions.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA