Naslov
Interspecies differences in PSA-NCAM zones in adult Teleostean brains

Autori
Labak, Irena ; Viljetić, Barbara ; Majić, Senka ; Heffer-Lauc, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts / - , 2010, 125-125

Skup
10th Congress of the Croatian Society of Biochemistry and Molecular Biology

Mjesto i datum
Opatija, Hrvatska, 15.09.2010. - 18.09.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
PSA-NCAM; neurogenesis; migration; brain; fishes

Sažetak
The neural cell adhesion molecule (NCAM) plays important role in adult neurogenesis, survival and migration of neuronal steam cells. Reversible attachment of polysialc acid (PSA) to extra cellular domain of NCAM promotes migration which is limited to rostral olfactory stream in the adult brain of mammals. Non-mammalian vertebrates poses much higher potential for regeneration due to constitutive adult neurogenesis, apoptotic elimination of damaged cells and efficient migration, differentiation and integration of newly derived cells in existing neural network. We compared expression of PSA-NCAM in carp (Cyprinus carpio), trout (Salmo gairdneri), perch (Perca fluviatilis) and pike (Esox lucius) brains with two different antibodies (mAb735 and clone 2-2B). PSA-NCAM zones in carp, trout and perch brain extend from telencephalon into cerebellum and mesencephalon. From the level of rostral mesencephalon toward spinal cord extensive PSA-NCAM zone exist just in pike brain. While two antibodies give similar result on trout and pike brains, reactivity of mAb735 is limited to cerebellar proliferation zone in perch and carp. Also, carp brain, contrary to any other, has proliferative zones in facial and vagal lobes - enlargement of nucleus solitarius connected with taste system and specialized palatal organ. PSA-NCAM is just one of the markers that are indicating potential for regeneration, but its expression in rhombencephalon and spinal cord of pike could be promising for spinal cord injury studies.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

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