Naslov
Sinteza novih N-sulfonilamidina pirimidinske serije
(Synthesis of novel N-sulfonylamidines in pyrimidine series)

Autori
Krstulović, Luka ; Bajić, Miroslav ; Višnjevac, Aleksandar ; Žinić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts, XXII. Hrvatski skup kemičara i kemijskih inženjera / Pičuljan, Katarina ; Smolec, Sonja - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2011, 41-41

ISBN
978-953-6894-38-3

Skup
XXII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 13.02.2011. - 16.02.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
N-sulfonilamidini ; pirimidini
(N-sulfonylamidines ; pyrinidines)

Sažetak
Amidines are found in many bioactive natural products [1] and identified as important pharmacophores [2]. Novel N-sulfonylamidines in pyrimidine series were utilized as a part of continous research on potential biologically active compounds. Synthesis involves three component, one-pot, copper catalyzed reaction of terminal alkyne, sulfonyl azide and amine. The reaction is propose to proceed via the formation of ketenimine intermediate, which is generated in situ by the Cu-catalyzed cycloaddition of sulfonyl azide with terminal alkynes followed by the ring opening of resultant triazole copper intermediate which reacts with amine to give three-component coupled product[3]. The structure of all compounds was confirmed on the basis of 1H, 13C NMR spectra and elemental analysis. Analysis by 2D NMR experiments confirmed anti-conformations of the products in DMSO solution and the same conformation was found by X-ray diffraction studies of some compounds. These products are under investigation for their biological activities.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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