Naslov
The Importance of homogeneous groups in psychiatric genetic research

Autori
Mimica, Ninoslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Neorologica Croatica 43(Suppl. 1) - Proceedings of the 34th International Neuropsychiatric Symposium in Pula / Barac, Boško ; Huber, Gerd ; Lechner, Helmut ; Muačević, Vasko - Pula : Croatian Neurological Society ; Croatian Neurosurgical Society, 1994, 27-28

Skup
34th International Neuropsychiatric Symposium in Pula

Mjesto i datum
Pula, Hrvatska, 01.06.1994. - 04.06.1994

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
genetic research; schizophrenia

Sažetak
Diagnostics of mental disorders is still based on symptomatology without other independent laboratory findings. Although psychiatric diseases are classified according to international statistical classification of diseases (ICD) or to Diagnostic and Statistical Manual of Mental Disorders (DSM), such approach is not sufficient enough for psychiatric-genetic research. In order to obtain more homogeneous groups of subjects, Spitzer et al developed Research Diagnostic Criteria (RCD) for a Selected Group of Functional Disorders. The authors assumed that for research purposes it was better to avoid false positives than false negatives, and for that reason the criteria were designed to reduce false positive findings. The RDC contains definitions of critical terms and diagnostic criteria for 24 functional psychiatric disorders and categories "currently not mentally ill" and "never mentally ill". With purpose to obtain all necessary data in a standardized way and for making the diagnosis according to RDC, Schedule for Affective Disorders and Schizophrenia (SADS) and Schedule for Affective Disorders and Schizophrenia - Life-time Version (SADS-L) were developed. SADS is used when detailed description of the current episode, as well as less detailed information on previous illness is desired. This schedule is very detailed and comprises 77 pages. In our psychiatric-genetic research we decided to abandon the use of this schedule. SADS-L is used when an investigator is primarily interested in diagnosis on the basis of life-time occurrence. SADS-L contains 46 pages and about 800 items, but many of these items can be skipped in the case of previous negative answer. To fulfill this structured interview it is usually necessary to spend about 90 minutes for each patient, and about 45 minutes for their relatives. Therefore, we decided together with investigators from Columbia University, New York, USA, to use SADS-L as a diagnostic instrument for schizophrenic patients and their relatives. This is performed within the frame of the research project "A genetic and epidemiological study of DNA markers related to schizophrenia in Croatia".

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Indexed/Abstracted in: Neuroscience Citation Index ; Bowker Int. Series Data Base

POVEZANOST RADA