Pregled bibliografske jedinice broj: 504461
Pentoxifylline treated MID patients ; results of a European double-blind placebo-controlled multicentre study
Pentoxifylline treated MID patients ; results of a European double-blind placebo-controlled multicentre study // Abstracts of the 26th Danube Symposium for Neurological Sciences
Innsbruck, 1993. str. 19-19 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
Pentoxifylline treated MID patients ; results of a European double-blind placebo-controlled multicentre study
Autori
Folnegović-Šmalc, Vera ; Kittner, Barbara ; Makarić, Gordan ; Mimica, Ninoslav ; Rößner, Martin
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Abstracts of the 26th Danube Symposium for Neurological Sciences
/ - Innsbruck, 1993, 19-19
Skup
26th Danube Symposium for Neurological Sciences
Mjesto i datum
Innsbruck, Austrija, 30.09.1993. - 02.10.1993
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
clinical trial; double-blind; pentoxifylline
Sažetak
In 29 European centers, 289 patients who met MID criteria according to DSM-III-R were enrolled. All patients had CT scan with at least one ischaemic lesion compatible with the diagnosis of MID, a Hachinski score of at least 7 and Mini Mental State examination between 10-25. The study was randomized and double-blind, 148 patients were on pentoxifylline and 141 on placebo, 47 patients dropped out before the end of the study. The Gottfries-Brane-Steen (GBS) scale was the primary efficacy criterion. The overall score£ improved by 0.7 points in the placebo group and by 3.5 points in the pentoxifylline group (p = 0.028). The subscore for intellectual function improved by 0.4 points in the placebo-treated patients and by 1.6 in the pentoxifylline group (p = 0.013). The total score of the SCAG showed an improvement of 4.2 points in the pentoxlfylline group and 2.6 points in the placebo group (p = 0.025). The cognitive function score improved by 1.7 points on trial medication and 0.5 on placebo (p = 0.005). The global ratings by relatives resulted in a significant difference after 3 and 6 months (p=0.050 after 3 months, p = 0.023 after 6 months and p = 0.090 after 9 months). According to the above mentioned results, we can conclude that this study demonstrates the efficacy of pentoxifylline in patients with multi-infarct dementia.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče
