Naslov
Clinical and molecular characterization of a parechovirus type 1 outbreak in neonates in Croatia

Autori
Ljubin-Sternak, Sunčanica ; Juretić, Emilija ; Šantak, Maja ; Pleša, Mirna ; Forčić, Dubravko ; Vilibić-Čavlek, Tatjana ; Aleraj, Borislav ; Mlinarić-Galinović, Gordana

Izvornik
Journal of medical virology (0146-6615) 83 (2011), 1; 137-141

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
parechovirus type 1; outbreak; neonates; Croatia

Sažetak
During July 2009 an outbreak in neonates represented with gastrointestinal and respiratory symptoms was observed at the Neonatal Postintensive Care Unit, Clinical Hospital Center, Zagreb. Human parechovirus type 1 (HPeV1) was isolated from seven patients, one of whom was asymptomatic. All but one were premature neonates with serious underlying conditions, and all recovered fully after several days. In order to characterize the HPeV1s, sequencing of the VP1/2A region was conducted on six isolates from the outbreak and four isolates detected in Croatia in 2008 and 2007. The analysis of sequence similarity showed that the nucleotide identity between the prototype strain (Harris) and HPeV1 isolated in Croatia was 76.5-77.5%. Croatian strains from 2007 and 2009 clustered together with strains from the Netherlands and Germany detected in 2003 and 2006, respectively, while strains from 2008 clustered with the strain from Finland detected in 2000. Change of the dominant strains each year may suggest antigenic variation as a result of viral response to specific immunity of the target population.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA