Naslov
Antioksidativna aktivnost hidroksamskih kiselina i hdroksiurea
(Antioxidant activity of hydroxamic acids and hydroxyureas)

Autori
Zovko Končić, Marijana ; Barbarić, Monika ; Perković, Ivana ; Joka, Tamara ; Miketić, Ivana ; Zorc, Branka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Knjiga sažetaka / Tomašić, Vesna ; Maduna Valkaj, Karolina - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2011, 219-219

ISBN
978-953-6894-42-0

Skup
XXII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 13.02.2011. - 16.02.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
hidroksamska kiselina; hidroksiurea; antioksidativno djelovanje
(hydroxamic acid; hydroxyurea; antioxidant activity)

Sažetak
A series of hydroxyureas (1-5) and hydroxamic acids (6-11) was synthesized according to our published procedures [1, 2]. Antioxidant activity in beta-carotene-linoleic acid assay, DPPH antiradical activity and Fe2+ chelating properties of the synthesized compounds were investigated. The antioxidant and antiradical activity of the compounds was compared (one-way ANOVA followed by Dunnett’s post hoc test) to the activity of well known antioxidant and radical scavenger butylated hydroxyanisol (BHA), while the iron chelating properties were compared to chelating properties of EDTA and quercetin. The investigated compounds were proven to be excellent antioxidants. This is especially true for hydroxamic acids 7-10 that were more effective in inhibiting beta-carotene-linoleic acid coupled oxidation than BHA. Moreover, all the compounds showed exceptional antiradical activities. For example, the activities of all hydroxyureas (1-5) and hydroxamic acid 11 were equal to the activity of BHA. In addition, most of the compounds (1, 6-10) were stronger Fe2+ ion chelators than quercetin, while the compounds 1, 7 and 9 were as successful Fe2+ ions chelators as EDTA. It is reasonable to assume that the antioxidant activity of the investigated compounds could contribute to their previously proven antiproliferative activities [2].

Izvorni jezik
Engleski

Znanstvena područja
Matematika, Kemija, Arhitektura i urbanizam

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