Naslov
Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers : a randomized, double-blind, placebo-controlled trial
(Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care center s: a randomized, double-blind, placebo-controlled trial)

Autori
Hojsak, Iva ; Snovak, Natalija ; Abdović, Slaven ; Szajewska, Hania ; Mišak, Zrinjka ; Kolaček, Sanja

Izvornik
Clinical nutrition (Edinburgh) (0261-5614) 29 (2010), 3; 312-316

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
LGG; children; gastrointestinal infections; respiratory tract infections; day care center

Sažetak
The aim of our study was to investigate the role of Lactobacillus GG (LGG) in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers. We conducted a randomized, double-blind, placebo-controlled trial in 281 children who attend day care centers. They were randomly allocated to receive LGG at a dose of 10(9) colony-forming units in 100ml of a fermented milk product (LGG group, n=139) or placebo that was the same post-pasteurized fermented milk product without LGG (placebo group, n=142) during the 3-month intervention period. Compared to the placebo group, children in the LGG group had a significantly reduced risk of upper respiratory tract infections (RR 0.66, 95% CI 0.52 to 0.82, NNT 5, 95% CI 4 to 10), a reduced risk of respiratory tract infections lasting longer than 3 days (RR 0.57, 95% CI 0.41 to 0.78, NNT 5, 95% CI 4 to 11), and a significantly lower number of days with respiratory symptoms (p<0.001). There was no risk reduction in regard to lower respiratory tract infections (RR 0.82, 95% CI 0.24 to 2.76). Compared with the placebo group, children in the LGG group had no significant reduction in the risk of gastrointestinal infections (RR 0.63, 95% CI 0.38 to 1.06), vomiting episodes (RR 0.60, 95% CI 0.29 to 1.24), and diarrheal episodes (RR 0.63, 95% CI 0.35 to 1.11) as well as no reduction in the number of days with gastrointestinal symptoms (p=0.063). LGG administration can be recommended as a valid measure for decreasing the risk of upper respiratory tract infections in children attending day care centers.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Rad je kao poster prezentiran na skupu ESPGHAN meeting, održanom od 03.-06.06.2009., Budimpešta, Mađarska ; sažetak je objavljen u časopisu Journal of Pediatric Gastroenterology and Nutrition (2009) 70-71 ; ISSSN 0277-2116

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