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Pregled bibliografske jedinice broj: 499521

Discovery of Novel Ureas and Thioureas of 3-Decladinosyl-3-hydroxy 15-Membered Azalides Active Against Efflux-mediated Resistant Streptococcus. Pneumoniae

Bukvić Krajačić, Mirjana; Dumić, Miljenko; Novak, Predrag; Cindrić, Mario; Koštrun, Sanja; Fajdetić, Andreja; Alihodžić, Sulejman; Brajša, Karmen; Kujundžić, Nikola
Discovery of Novel Ureas and Thioureas of 3-Decladinosyl-3-hydroxy 15-Membered Azalides Active Against Efflux-mediated Resistant Streptococcus. Pneumoniae // Bioorganic & medicinal chemistry letters, 21 (2011), 2; 853-856 doi:10.1016/j.bmcl.2010.11.079 (međunarodna recenzija, članak, znanstveni)

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Naslov
Discovery of Novel Ureas and Thioureas of 3-Decladinosyl-3-hydroxy 15-Membered Azalides Active Against Efflux-mediated Resistant Streptococcus. Pneumoniae

Autori
Bukvić Krajačić, Mirjana ; Dumić, Miljenko ; Novak, Predrag ; Cindrić, Mario ; Koštrun, Sanja ; Fajdetić, Andreja ; Alihodžić, Sulejman ; Brajša, Karmen ; Kujundžić, Nikola

Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 21 (2011), 2; 853-856

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azalides ; 3-decladinosyl ; ureas ; thioureas ; synthesis ; antibacterial activity

Sažetak
A series of novel ureas and thioureas of 3-decladinosyl-3-hydroxy 15-membered azalides, were discovered, structurally characterized and biologically evaluated. They have shown good antibacterial activity against selected Gram-positive and Gram-negative bacterial strains. These include N00 substituted 9a-(N0-carbamoyl-c-aminopropyl)- (6a, c), 9a-(N0-thiocarbamoyl-c-aminopropyl)- (7a, e), 9a-[N0-(b-cyanoethyl)- N0-(carbamoyl-c-aminopropyl)]- (9a–c, 9g) 9a-[N0-(b-cyanoethyl)-N0-(thiocarbamoyl-c-aminopropyl)]- derivatives (10d–f) of 5-O-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerythronolide A (3). Among the synthesized compounds thiourea 7a and urea 9b have shown substantially improved activity comparable to azithromycin (1) and significantly better activity than the 3-decladinosyl-azithromycin (2) and the parent 3-cladinosyl analogues against efflux-mediated resistant S. pneumoniae.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Novak, Predrag, MZOS ) ( CroRIS)
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Sanja Koštrun (autor)

Avatar Url Nikola Kujundžić (autor)

Avatar Url Andreja Fajdetić (autor)

Avatar Url Sulejman Alihodžić (autor)

Avatar Url Predrag Novak (autor)

Avatar Url Mirjana Bukvić (autor)

Avatar Url Miljenko Dumić (autor)

Avatar Url Mario Cindrić (autor)

Avatar Url Karmen Brajša (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com doi.org

Citiraj ovu publikaciju:

Bukvić Krajačić, Mirjana; Dumić, Miljenko; Novak, Predrag; Cindrić, Mario; Koštrun, Sanja; Fajdetić, Andreja; Alihodžić, Sulejman; Brajša, Karmen; Kujundžić, Nikola
Discovery of Novel Ureas and Thioureas of 3-Decladinosyl-3-hydroxy 15-Membered Azalides Active Against Efflux-mediated Resistant Streptococcus. Pneumoniae // Bioorganic & medicinal chemistry letters, 21 (2011), 2; 853-856 doi:10.1016/j.bmcl.2010.11.079 (međunarodna recenzija, članak, znanstveni)
Bukvić Krajačić, M., Dumić, M., Novak, P., Cindrić, M., Koštrun, S., Fajdetić, A., Alihodžić, S., Brajša, K. & Kujundžić, N. (2011) Discovery of Novel Ureas and Thioureas of 3-Decladinosyl-3-hydroxy 15-Membered Azalides Active Against Efflux-mediated Resistant Streptococcus. Pneumoniae. Bioorganic & medicinal chemistry letters, 21 (2), 853-856 doi:10.1016/j.bmcl.2010.11.079.
@article{article, author = {Bukvi\'{c} Kraja\v{c}i\'{c}, Mirjana and Dumi\'{c}, Miljenko and Novak, Predrag and Cindri\'{c}, Mario and Ko\v{s}trun, Sanja and Fajdeti\'{c}, Andreja and Alihod\v{z}i\'{c}, Sulejman and Braj\v{s}a, Karmen and Kujund\v{z}i\'{c}, Nikola}, year = {2011}, pages = {853-856}, DOI = {10.1016/j.bmcl.2010.11.079}, keywords = {azalides, 3-decladinosyl, ureas, thioureas, synthesis, antibacterial activity}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2010.11.079}, volume = {21}, number = {2}, issn = {0960-894X}, title = {Discovery of Novel Ureas and Thioureas of 3-Decladinosyl-3-hydroxy 15-Membered Azalides Active Against Efflux-mediated Resistant Streptococcus. Pneumoniae}, keyword = {azalides, 3-decladinosyl, ureas, thioureas, synthesis, antibacterial activity} }
@article{article, author = {Bukvi\'{c} Kraja\v{c}i\'{c}, Mirjana and Dumi\'{c}, Miljenko and Novak, Predrag and Cindri\'{c}, Mario and Ko\v{s}trun, Sanja and Fajdeti\'{c}, Andreja and Alihod\v{z}i\'{c}, Sulejman and Braj\v{s}a, Karmen and Kujund\v{z}i\'{c}, Nikola}, year = {2011}, pages = {853-856}, DOI = {10.1016/j.bmcl.2010.11.079}, keywords = {azalides, 3-decladinosyl, ureas, thioureas, synthesis, antibacterial activity}, journal = {Bioorganic and medicinal chemistry letters}, doi = {10.1016/j.bmcl.2010.11.079}, volume = {21}, number = {2}, issn = {0960-894X}, title = {Discovery of Novel Ureas and Thioureas of 3-Decladinosyl-3-hydroxy 15-Membered Azalides Active Against Efflux-mediated Resistant Streptococcus. Pneumoniae}, keyword = {azalides, 3-decladinosyl, ureas, thioureas, synthesis, antibacterial activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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