Naslov
Expression of endothelial selectin ligands on leukocytes following repeated dives in scuba divers

Autori
Čikeš Čulić, Vedrana ; Martinić, Roko ; Markotić, Anita ; Ljubković, Marko ; Brešković, Toni ; Marinović, Jasna ; Dujić, Željko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FEBS J / - , 2010, 277:45-45

Skup
35TH FEBS CONGRESS MOLECULES OF LIFE

Mjesto i datum
Göteborg, Švedska, 26.06.2010. - 01.07.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
monocyte; granulocyte; CD15; CD15s; trimix

Sažetak
Leukocyte cell surface adhesion molecule CD11b, decorated with CD15s, plays a critical role in regulation of β2 integrin functions during neutrophile endothelial transmigration. Hyperbaric oxygenation reduces neutrophile-endothelial cell adhesion which is mediated by Mac-1 (CD11b/CD18) β2-integrin. This study investigated expression of CD15 and CD15s, on leukocytes following repeated trimix (a mixture of oxygen, helium and nitrogen) dives in two series: in the first series 7 divers performed 6 consecutive dives from 55-80 m (total dive time varied from 65-75 min), while in the second series 7 divers performed 3 consecutive dives from 63-65 m (total dive time varied from 59-83 min). A more intense dive profile was used in the second series, as can be seen from the longer total dive time. Five divers took part in each of the two series. CD15 and CD15s were determined before and after the 1st and the last dive. Leukocyte subpopulations were not elevated after either the first or last dives in series I. Only CD15s+ granulocytes were significantly decreased after the first dive. In the second series the monocyte proportion was increased and lymphocyte decreased within total leukocyte population, while CD15s+ monocytes and CD14+CD15s+ granulocytes were elevated after the first and the last dive in the second series. The current findings of decreased endothelial selectin ligand CD15s expression on CD15+ granulocytes after certain dives point to the role of this subpopulation in the endothelial damage prevention.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA