Naslov
Liver regeneration in perforin-deficient mice

Autori
Radošević-Stašić, Biserka ; Trobonjača, Zlatko ; Ravlić-Gulan, Jagoda ; Ćuk, Mira ; Mrakovčić-Šutić, Ines ; Rukavina, Daniel

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Programme, Abstacts / Hrvatsko imunološko društvo - Zagreb : Hrvatsko imunološko društvo, 1999

Skup
Annual meeting of the Croatian Immunological Society

Mjesto i datum
Zagreb, Hrvatska, 25.11.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
liver regeneration; perforin-deficient mice

Sažetak
To test the possible role of cytotoxic T and NK cells in the control of normal growth in this study the liver regeneration was analyzed in perforin knock out (PKO) mice, which have normal numbers of CD8+ and NK+ cells, but owing to the lack of a key effector molecule are unable to lyze the transformed targets. The data showed that 24 hours and 7 days after 1/3 pHx in regenerating liver of wild mice the percentage of cells in G2/M phase increased. In contrast to this, PKO mice, had initially smaller (on 1st day) and then greater (at 3rd and 7th day ) fraction of cells in G2+M phase of cell cycle, suggesting that the response to pHx in the PKO mice was significantly delayed, and implying the local role of T and/or NK-cell mediated cytolytic mechanisms in the control of liver

Izvorni jezik
Engleski

POVEZANOST RADA