Alpha- and LHbeta- subunit determination in the patients with nonfunctioning pituitary adenomas

Breskovac, Ljiljana; Plavšić, Vesna; Koršić, Mirko; Žarković, Neven; Tomašić, Jelka; Žarković, Kamelija; Giljević, Zlatko; Aganović, Izet

Pregled bibliografske jedinice broj: 49599

Alpha- and LHbeta- subunit determination in the patients with nonfunctioning pituitary adenomas

Breskovac, Ljiljana; Plavšić, Vesna; Koršić, Mirko; Žarković, Neven; Tomašić, Jelka; Žarković, Kamelija; Giljević, Zlatko; Aganović, Izet

Alpha- and LHbeta- subunit determination in the patients with nonfunctioning pituitary adenomas // Abstracts of the 17th International and 13th European Congress of Clinical Chemistry and Laboratory Medicine ; u Clinical Chemistry and Laboratory Medicine 137 (1999) (Spec. Suppl.) ; M229 / Siest, Gerard (ur.).
Berlin : New York: Walter de Gruyter, 1999. str. 174-174 (poster, međunarodna recenzija, sažetak, znanstveni)

CROSBI ID: 49599 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Alpha- and LHbeta- subunit determination in the patients with nonfunctioning pituitary adenomas

Autori
Breskovac, Ljiljana ; Plavšić, Vesna ; Koršić, Mirko ; Žarković, Neven ; Tomašić, Jelka ; Žarković, Kamelija ; Giljević, Zlatko ; Aganović, Izet

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 17th International and 13th European Congress of Clinical Chemistry and Laboratory Medicine ; u Clinical Chemistry and Laboratory Medicine 137 (1999) (Spec. Suppl.) ; M229 / Siest, Gerard - Berlin : New York : Walter de Gruyter, 1999, 174-174

Skup
17th International Congress of Clinical Chemistry and Laboratory Medicine (17 ; 1999) ; European Congress of Clinical Chemistry and Laboratory Medicine (13 ; 1999)

Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
nonfunctioning pituitary adenomas; TRH test; LH beta; alpha-subunit

Sažetak
Paradoxical responses of gonadotropins and their subunits in TRH test have been reported in patients with clinically nonfunctioning pituitary adenomas (NFPA). In the present study we have made an in-house RIA for measuring LHbeta- subunit and alpha-subunit (alpha-SU) responses to TRH in 33 patients with NFPA and their concentrations in cell culture media of 9 NFPA. Thirteen of 33 patients (39.4 percent) had significant serum LHbeta responses to TRH and 18/33 (54.5 percent) had significant alpha-SU responses. Six of nine (66.7 percent) cultivated NFPA secreted Lhbeta and 8/9 (88.8 percent) secreted alpha-SU into the cell culture media. A significant correlation was obtained between the quantity of alpha-SU and LHbeta released in vitro and their maximal percent responses to TRH in vivo. The results indicate that the majority of NFPA (75.8 percent) can be recognized as of gonadotroph origin by a combination of LHbeta and/or alpha-SU responses to TRH.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
108116

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Vesna Plavšić (autor)