Pregled bibliografske jedinice broj: 495894
Role of 5-HT1A receptors in induction and preservation of phrenic long-term facilitation in rats
Role of 5-HT1A receptors in induction and preservation of phrenic long-term facilitation in rats // Respiratory Physiology & Neurobiology, 175 (2011), 1; 146-152 doi:10.1016/j.resp.2010.10.005 (međunarodna recenzija, članak, znanstveni)
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Naslov
Role of 5-HT1A receptors in induction and preservation of phrenic long-term facilitation in rats
Autori
Pavlinac, Ivana ; Pecotić, Renata ; Đogaš, Zoran ; Valić, Maja
Izvornik
Respiratory Physiology & Neurobiology (1569-9048) 175
(2011), 1;
146-152
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
phrenic nerve; intermittent hypoxia; serotonin
Sažetak
The aim was to investigate the role of 5-HT(1A) receptor activation in induction and preservation of phrenic long-term facilitation (pLTF) at two different time points, before exposures to episodic hypoxia and after pLTF was induced. Adult, male, urethane anesthetized, vagotomized, paralyzed, and mechanically ventilated Sprague-Dawley rats were exposed to an acute intermittent hypoxia (AIH) protocol. Experimental groups of animals received an intravenous injection of WAY-100635, before the onset of the first hypoxic stimulus (WAY0), and after pLTF was induced (WAY60). Peak phrenic nerve activity (pPNA), burst frequency (f), and respiratory rhythm parameters were analyzed during the five hypoxic exposures (TH1-5), as well as at 15min (T15), 30min (T30), and 60min (T60) after the end of the last hypoxic episode. In the control group, pPNA was elevated from baseline (121.6±7.3%, P<0.001) at 60min after episodic hypoxia indicating pLTF. Administration of WAY-100635 prior to hypoxic stimulation prevented the induction of pLTF. Additionally, administration of WAY-100635 after pLTF developed impaired preservation of pLTF. In conclusion, there is an important role for 5-HT(1A) receptors in induction as well as in preservation of pLTF in urethane anesthetized rats
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
216-2163166-0513 - Neuralna kontrola disanja u budnosti i spavanju (Đogaš, Zoran, MZOS ) ( CroRIS)
216-2163166-3342 - Središnja regulacija kardiovaskularnog i respiracijskog sustava-uloga serotonina (Valić, Maja, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Split
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE