Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 489816

Poly(ADP)ribose polymerase in the biology of glioblastoma cells


Madunić, Josip; Antica, Mariastefania; Matulić, Maja
Poly(ADP)ribose polymerase in the biology of glioblastoma cells // Book of Abstracts of "HDIR-1: From Bench to Clinic" - First Meeting of the Croatian Association for Cancer Research with International Participation / Sabol, Maja ; Levanat, Sonja (ur.).
Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2010. str. 77-77 (poster, domaća recenzija, sažetak, znanstveni)


CROSBI ID: 489816 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Poly(ADP)ribose polymerase in the biology of glioblastoma cells

Autori
Madunić, Josip ; Antica, Mariastefania ; Matulić, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts of "HDIR-1: From Bench to Clinic" - First Meeting of the Croatian Association for Cancer Research with International Participation / Sabol, Maja ; Levanat, Sonja - Zagreb : Hrvatsko društvo za istraživanje raka (HDIR), 2010, 77-77

Skup
"HDIR-1: From Bench to Clinic" - First Meeting of the Croatian Association for Cancer Research with International Participation

Mjesto i datum
Zagreb, Hrvatska, 11.11.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
poly(ADP)ribose polymerase

Sažetak
Poly(ADP)polymerase-1 (PARP-1) is a nuclear protein involved in the posttranslational process of poly(ADPribos)ylation, synthesis of ADP-ribose polymer on target proteins. It has an important role in maintaining genome integrity. Its enzymatic activity is highly induced by DNA strand breaks, when it recruits damage repair proteins to the DNA. PARP-1 has also a role in the regulation of transcription and chromatin structure, as well as in DNA methylation. In our study we investigated the role of PARP-1 in the biology of the A1235 human glioblastoma cell line. Cells were treated with sublethal doses of alkylating agent N-methyl-N'-nitro- N-nitrosoguanidine (MNNG), either alone or in combination with PARP-1 inhibitor. We analyzed cell proliferation, appearance of senescent cells, changes in cell morphology, cell cycle and effects on the urokinase plasminogen activator induction. Although PARP-1 inhibitors slightly decreased cell proliferation when added with MNNG in comparison with the alkylating agent alone, both treatments similarly affected cell cycle (accumulation of cells in S and G2 cell cycle phase) and also induced senescence. On the other side, activity of the extracellular protease, urokinase plasminogen activator, known to be induced in A1235 cells by alkylating agents, was modulated by the PARP-1 inhibitor. The mechanisms of PARP-1 regulation in the process of transcription will be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
098-0982913-2332 - Molekularne interakcije u diferencijaciji limfocita (Antica, Mariastefania, MZOS ) ( CroRIS)
119-0000000-3172 - Poli(ADPribozilacija, starenje i plazminogenska aktivacija u tumorskim stanicama (Matulić, Maja, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Mariastefania Antica (autor)

Avatar Url Josip Madunić (autor)

Avatar Url Maja Matulić (autor)

Citiraj ovu publikaciju:

Madunić, Josip; Antica, Mariastefania; Matulić, Maja
Poly(ADP)ribose polymerase in the biology of glioblastoma cells // Book of Abstracts of "HDIR-1: From Bench to Clinic" - First Meeting of the Croatian Association for Cancer Research with International Participation / Sabol, Maja ; Levanat, Sonja (ur.).
Zagreb: Hrvatsko društvo za istraživanje raka (HDIR), 2010. str. 77-77 (poster, domaća recenzija, sažetak, znanstveni)
Madunić, J., Antica, M. & Matulić, M. (2010) Poly(ADP)ribose polymerase in the biology of glioblastoma cells. U: Sabol, M. & Levanat, S. (ur.)Book of Abstracts of "HDIR-1: From Bench to Clinic" - First Meeting of the Croatian Association for Cancer Research with International Participation.
@article{article, author = {Maduni\'{c}, Josip and Antica, Mariastefania and Matuli\'{c}, Maja}, year = {2010}, pages = {77-77}, keywords = {poly(ADP)ribose polymerase}, title = {Poly(ADP)ribose polymerase in the biology of glioblastoma cells}, keyword = {poly(ADP)ribose polymerase}, publisher = {Hrvatsko dru\v{s}tvo za istra\v{z}ivanje raka (HDIR)}, publisherplace = {Zagreb, Hrvatska} }
@article{article, author = {Maduni\'{c}, Josip and Antica, Mariastefania and Matuli\'{c}, Maja}, year = {2010}, pages = {77-77}, keywords = {poly(ADP)ribose polymerase}, title = {Poly(ADP)ribose polymerase in the biology of glioblastoma cells}, keyword = {poly(ADP)ribose polymerase}, publisher = {Hrvatsko dru\v{s}tvo za istra\v{z}ivanje raka (HDIR)}, publisherplace = {Zagreb, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font