Pregled bibliografske jedinice broj: 489340
Antioxidant enzyme status in NOD mouse embryos during diabetic pregnancy
Antioxidant enzyme status in NOD mouse embryos during diabetic pregnancy // The secret life of biomolecules
Opatija, 2010. str. 117-117 (poster, domaća recenzija, sažetak, znanstveni)
CROSBI ID: 489340 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Antioxidant enzyme status in NOD mouse embryos during diabetic pregnancy
Autori
Korolija, Marina ; Popović Hadžija, Marijana ; Sobočanec, Sandra ; Šarić, Ana ; Hadžija, Mirko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
The secret life of biomolecules
/ - Opatija, 2010, 117-117
Skup
10th Congress of the Croatian society of biochemistry and molecular biology
Mjesto i datum
Opatija, Hrvatska, 15.09.2010. - 18.09.2010
Vrsta sudjelovanja
Poster
Vrsta recenzije
Domaća recenzija
Ključne riječi
Antioxidant; NOD; diabetes; NTDs
Sažetak
Maternal diabetes increases the rate of congenital malformations in embryos, causing diabetic embryopathy. Although the cellular and molecular mechanisms of diabetic embryopathy are poorly understood, it was shown that maternal hyperglycemia induces oxidative stress in embryos. In this work, we have employed non-obese diabetic (NOD) mouse strain as a model of diabetic embryopathy. In order to assess the incidence of neural tube defects (NTDs), we analyzed external morphology of E (embryonic day) 10, 5 embryos from non-diabetic and alloxan-induced diabetic pregnancies. We found exencephaly as the most common defect, affecting nearly 10 % of all embryos developed under high glucose conditions. Moreover, we analyzed the antioxidant enzyme gene and protein expression in all samples, observing the influence of hyperglycemia only at the translational level.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
098-0982464-1647 - Sustav citokroma P450 i pojava tumora u starenju i oksidacijskom stresu (Balog, Tihomir, MZOS ) ( CroRIS)
098-0982464-2460 - Dobivanje struktura nalik Langerhansovim otočićima iz matičnih stanica miša (Hadžija, Mirko, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Ana Šarić
(autor)
Marijana Popović-Hadžija
(autor)
Mirko Hadžija
(autor)
Marina Korolija
(autor)
Sandra Sobočanec
(autor)