Naslov
Investigation of the Antimycotic Activities of Solidago virgaurea and Solidago gigantea Exstracts

Autori
Pepeljnjak, Stjepan ; Kuštrak, Danica ; Vukušić, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Program and Abstracts / Gerhard, Franz ; Vieweger, Urlike - Regensburg, 1997

Skup
45th Annual Congress of the Society for Medicinal Plant Research

Mjesto i datum
Regensburg, Njemačka, 07.09.1997. - 12.09.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Solidago virgaurea; Solidago gigantea; antimycotic activity

Sažetak
Solidago species (Asteraceae) have been used for centuries in folk medicine for the treatment of chronic nephritis, urolithiasis, cystitis, rheumatism, ulceration and as an atiflogistic drug. Solidago virgaurea and S. gigantea contain polysaccharides, flavonoid glycosides, triterpenoid saponins, tannins, phenolglycosides and volatile oils. The plant ethanolic extracts (E:E) which contain either saponins flavonoids tannins and essential oils have antimicrobial properties. Growth inhibition is influenced particulary by the carbohydrate chains of the glycosides. Monodesmosidic as well as bismodesmosidic glycosides of polygalacic acid exert fungicide effects. The water-soluble polysaccharides from Solidago species were isolated and tested for antitumor effects. In our study we have tested the antimycotic activity of ethanolic extracts (1:1) and saponins complex. E:E. were prepared from dried, aerial parts of S. virgaurea and S. gigantea collected at the flowering stage in August and early in September. Saponin complex was prepared from dried leaves S. gigantea. The atimycotic activity was tesetd by the method of diffusion and dilution on Sabouraud dextrose bouillon and sabouraud dextrose agar. Various strains of Candida species and dermatophytes were used. Antifungal activity of the E:E was established: Candida pseudotropicalis and C. albicans (MIC 25 %), C. krusei (MIC 27.5 %) from S. gigantea extracts and as well as a small activity of S: virgaurea extracts upon C. albicans (MIC 40 %), C. krusei and C. tropicalis (MIC 50 %). E:E the both herbs had fungicidal effect on Trichophyton mentagrophytes (MIC 14-30 %), T. schonleini (MIC 20-30 %), Microsporum gypseum (MIC 9.7 %) and M. canis (MIC 33 %). Saponin complex from S. gigantea do not express antifungal activity on candida and dermatophyte species.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA