Naslov
The clinical revalence of p53 isoforms in ovarian cancer

Autori
Hofstetter, Gerda ; Concin, Nicole ; Berger, Astrid ; Fiegl, Heidi ; Slade, Neda ; Zorić, Arijana ; Tong, D ; Holzer, Barbara ; Schuster, E. ; Wolf, Andrea ; Marth, Christian ; Zeimet, Alain ; Zeillinger, Robert

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
P53 isoforms through evolution: from identification to biological function / - Lyon : International Agency for Research on Cancer (IARC), 2010, 44-44

Skup
1st International p53 Isoforms Meeting

Mjesto i datum
Lyon, Francuska, 2010

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
p53 splicing variant ; p73 ; ovarian carcinoma

Sažetak
P53 splice variants were present in 18 of 34 ovarian cancer cell lines (52.9%) and 134 of 245 primary ovarian cancers (54.7%). p53delta expression was associated with impaired response to primary platinum-based chemotherapy (P=0.032). Also, p53delta expression constituted an independent prognostic marker for recurrence-free and overall survival (hazard ratio 1.854, 95% confidence interval 1.121–3.065, P=0.016 ; and hazard ratio 1.937, 95% confidence interval 1.177–3.186, P=0.009, respectively). p53beta expression was associated with adverse clinicopathologic markers, that is, serous and poorly differentiated cancers (P=0.002 and P=0.008, respectively), and correlated with worse recurrence-free survival in patients exhibiting functionally active p53 (P=0.049).

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA