Naslov
Osteogenic potein-1 mRNA in the uterine endometrium
(Osteogenic protein-1 mRNA in the uterine endometrium)

Autori
Ozkaynak, Engin ; Jin, Donald ; Jelić, Mislav ; Vukičević, Slobodan ; Oppermann, Herman

Izvornik
Biochemical and biophysical research communications (0006-291X) 234 (1997), 1; 242-246

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
osteogenic protein-1; endometrium

Sažetak
OP-1, a bone morphogenetic protein (BMP) in the TGF-B superfamily, is expressed at high levels in the kidney and in the endometrium of the uterus of nonpregnant mice. During pregnancy the OP-1 mRNA in the endometrium rapidly declined at 4 dpc. Thereafter, OP-1 transcripts were detected in the trophoblastic giant cells of the placenta and the fetal tissues. The uterine OP-1 mRNA downregulation could be mimicked by administration of 17 B-estradiol but not by progesterone to non-pregnant animals. In contrast, OP-1 mRNA expression in kidneys and ovaries was not affected by pregnancy or estrogen treatment. The selective effect of estrogen on OP-1 mRNA in the uterus suggests that OP-1 expression is regulated by tissue specific mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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