Naslov
The role of CD23 antigen in IgE regulation in atopic dermatitis patients

Autori
Lipozenčić, Jasna ; Gagro, Alenka ; Rabatić, Sabina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Australasian Journal of Dermatology / Dyall-Smith, Delwyn - Carlton : Wiley-Blackwell, 1997, 61-61

Skup
19th World congress of dermatology

Mjesto i datum
Sydney, Australija, 15.06.1997. - 20.06.1997

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
atopic dermatitis; CD23 antigen

Sažetak
Atopic dermatitis (AD) shows a variety of humoral and cell-mediated immune dysfunctions, including elevation of serum IgE level; multiple positive immediate skin tests to a variety of antigens; CD8+T cells that disturb the regulatory function of CD4+T cells concerned with enhancement of IgE production; CD23 and CD21 antigen that participate in the control of IgE synthesis. Signas mediated through CD21/CD23 interaction seems to be very important in IgE antibody production. Aim was in 33 AD patients to investigate expression of CD23 and CD21 molecules on B cells, possible correlation between total IgE and CD23 antigen and existence of T cell activation (HLA-DR expression). Three colour immunofluorescence analysis on a flow cytometer using "Whole blood" immunoluorescence staining with monoclonal antibodies for surface marker analysis and total serum IgE with Prist kit were used. Patients with AD had increased % of total CD23 lymphocytes and % of CD23+ in B lymphocytes when compared with controls, CD23+lymphocytes positively correlated with total IgE levels in sera od AD patients. Increase percentage of CD23+in B lymphocytes in patients with normal IgE levels suggests the existence of B cell activation that is indipendent od IL-4. Experimental evidence that factors important for IgE regultation change the phenotype of B cells defined by expression of CD21 and CD23 antigen.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA