Naslov
Determination of peripheral blood T and B cell activation antigens in patients with atopic dermatitis

Autori
Lipozenčić, Jasna ; Gagro, Alenka ; Rabatić, Sabina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
JEADV : Book of Abstracts / Lotti, Torelo - Amsterdam : Elsevier, 1996, 107-107

Skup
5th Congress of the European Academy of Dermatology and Venereology

Mjesto i datum
Lisabon, Portugal, 13.10.1996. - 17.10.1996

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
atopic dermatitis; T and B cell activation in peripheral blood

Sažetak
Atopic dermatitis (AD) is clinical entity with multifactorial causes. The opinions on diagnostic procedure to confirm the type I and IV of immune mechanisms in pathogenesis of AD are conflicting in the literature. The aim of our study was to investigate the expression of CD23 and CD21 molecules on B cells, known to participate in the control of IgE synthesis, andHLA-DR (activation antigen) on T-cells in patients with AD and compare it to healthy controls. Peripheral blood samples were obtained from 32 patients with AD (12 male and 20 female, aged from 4-40 years) and anlyzed by 3-colour immunofluorescence analysis on a flow cytometer. In our study we observed that AD patients had increased % of total CD 23 lymphocytes and % of CD23+in B lymphocytes when compared with controls. In sera od AD patients percentage of CD23+ B lymphocites positively correlated with total IgE levels. Increased percentage of CD23+ in B lymphocytes in our AD patients with normal IgE levels in comparison to healthy controls suggests existence of B cell activation that is indiependent of IL-4.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA