Naslov
Baseline analysis: a simple FT-IR method for obtaining phase transition temperatures

Autori
Zimmermann, Boris ; Baranović, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
30th European Congress on Molecular Spectroscopy: EUCMOS 2010 : Book of Abstracts / Maurizio Becucci ; Cristina Gellini ; Vincenzo Schettino - Firenza : München : EUCMOS, 2010, 57-57

Skup
30th European Congress on Molecular Spectroscopy

Mjesto i datum
Firenca, Italija, 29.08.2010. - 03.09.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
baseline; infrared spectroscopy; phase transition; thermal analysis; polymorphism; mesomorphism

Sažetak
The baseline analysis designates an analysis of the absolute baseline variations obtained from the temperature-dependent transmittance mid-IR spectra at an arbitrarily chosen wavenumber assumed to be free of sample absorption (most often at around 2000 cm-1). A simple plot showing transmittance (absorbance) at a given wavenumber versus temperature is found to be sufficient for obtaining phase transition temperatures. The method is rapid, inexpensive and completely free of any personal bias. The method efficiency was corroborated by measuring various phase phenomena, including polymorphism (different ways of molecular packing in the solid state) and mesomorphism (liquid crystals), as well as chemical reactions [1]. The baseline analysis is of particular importance to pharmaceutical industry since the solid state of active pharmaceutical ingredient (API) can drastically alter the bioavailability of the drug. The wide-ranging potential of the baseline analysis for simple and reliable routine screening studies of API polymorphism is established on the model drug paracetamol. An additional prospect of the method as an economical way of establishing critical temperature regions is demonstrated on determination of glass transition of polymers (polystyrene, polyvinyl chloride, poly(methyl methacrylate), polyethylene terephthalate and polycarbonate).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA