Naslov
Antimicrobial activity of Thymus longicaulis C. Presl essential oil against respiratory tract pathogens

Autori
Vladimir-Knežević, Sanda ; Kosalec, Ivan ; Petrović, Marinko ; Ralić, Jovica ; Matica, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research : abstracts ; u: Planta Medica 76 (2010) (12) ; P503 / Melzig, Matthias F. ; Kolodziej, Herbert - Stuttgart : Georg Thieme Verlag, 2010, 1320-1320

Skup
International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (58 : 2010)

Mjesto i datum
Berlin, Njemačka, 29.08.2010. - 02.09.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Thymus longicaulis C. Presl; essential oil; GC-MS; antimicrobial activity

Sažetak
Thymus longicaulis C. Presl is a small aromatic perennial herb of Lamiaceae family and a typical representative of the Illyric-Mediterranean flora. This species is a traditional remedy for cold, flu, cough, nephritis and abdominal pain [1]. Present study aimed to evaluate composition of essential oil and its in vitro antimicrobial activity against major respiratory tract pathogens which show increasing resistance to commonly prescribed antimicrobials [2]. The yield of essential oil obtained by hydrodistillation from aerial plant parts was 12 ml/kg. According to the GC-MS analysis, a total of 41 compounds (99%) were identified. Thymol (46.3%), γ-terpinene (16.2%), thymyl methyl ether (11.4%), and p-cymene (9.4%) were the main components. Antimicrobial activity of the essential oil was determined using microdilution broth assay (tested concentrations were 0.2-25 mg/ml). Amoxicillin-clavulanate and fluconazole were used in order to control sensitivity of tested clinically isolated bacterial and yeast strains: Haemophilus influenzae, Neisseria meningitidis, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes and Candida albicans. The essential oil exhibited antimicrobial activity against all tested pathogens. The most sensitive strains were H. influenzae and S. pneumoniae (MIC 0.78 mg/ml), while S. aureus was the most resistant (MIC > 25 mg/ml). Our results revealed that T. longicaullis from Croatia is rich in essential oil characterized by a high content of thymol. A strong antimicrobial effect of the essential oil proved in this study indicates on its huge potential in the treatment of respiratory tract infections. References: 1. Kütür, S. (2007) J. Ethnopharmacol. 111:341–364. 2. Klugman, K.P. (2007) Int. J. Antimicrob. Agents 29:6-10.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

Napomena
DOI: 10.1055/s-0030-1264801

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