Naslov
DMSA treatment during lead exposure in suckling rats

Autori
Varnai, Veda Marija ; Piasek, Martina ; Blanuša, Maja ; Matek, Marijana ; Kostial, Krista

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts from the 6th International Symposium on Chelating Agents in Pharmacology, Toxicology and Therapeutics, Biomarkers and Environment. Vol. 3, No. 3, 4 / Topolčan, Ondrej - Plzeň : CECHTUMA, s.r.o., 2000, 11-11

Skup
International Symposium on Chelating Agents in Pharmacology, Toxicology and Therapeutics (6 ; 2000)

Mjesto i datum
Plzeň, Češka Republika, 07.09.2000. - 09.09.2000

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
meso-2; 3-dimercaptosuccinic acid; lead poisoning; gastrointestinal absorption; body retention; young; rat

Sažetak
The aim of this study was to evaluate the effect of oral DMSA treatment in suckling rats during oral lead exposure. The experiment lasted nine days and was conducted on suckling Wistar rats (day 6-14 after birth). All pups were artificially fed on cow's milk by means of a dropper, during about 6 h per day and were orally exposed to lead (as lead acetate, 2 mg Pb/kg body wt./day, administered in distilled water twice during each day ; total dose administered: 16 mg Pb/kg body wt.). Sucklings were divided into two groups: controls – untreated, and experimental – treated with DMSA. Each group consisted of ten pups from five different litters. DMSA was given orally at a daily dose of 0.5 mmol/kg body wt., administered twice a day, immediately after lead administration, through six days (on experimental days 1-3 and 6-8 ; total dose: 3 mmol/kg body wt.). Pups were killed by abdominal aortal exsanguination in ether anaesthesia at the end of the experiment. Lead was analysed in tissues by atomic absorption spectrometry. By DMSA treatment lead concentrations in suckling rats were significantly decreased as compared to controls in all analysed tissues: in the liver (67%), brain (56%), kidneys (40%), and carcass (27%). The finding that DMSA can be used during ongoing lead exposure might be relevant to many cases when increased lead exposure in infants and young children could not be avoided.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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