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Pregled bibliografske jedinice broj: 479385

400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens

Fajdetić, Andreja; Čipčić Paljetak, Hana; Lazarevski, Gorjana; Hutinec, Anton; Alihodžić, Sulejman; Ðerek, Marko; Štimac, Vlado; Andreotti, Danielle; Šunjić, Vitomir; Berge, John et al.
400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens // Bioorganic & medicinal chemistry, 18 (2010), 17; 6559-6568 doi:10.1016/j.bmc.2010.06.049 (međunarodna recenzija, članak, znanstveni)

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Naslov
400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens

Autori
Fajdetić, Andreja ; Čipčić Paljetak, Hana ; Lazarevski, Gorjana ; Hutinec, Anton ; Alihodžić, Sulejman ; Ðerek, Marko ; Štimac, Vlado ; Andreotti, Danielle ; Šunjić, Vitomir ; Berge, John ; Mutak, Stjepan ; Dumić, Miljenko ; Lociuro, Sergio ; Holmes, David ; Maršić, Nataša ; Eraković Haber, Vesna ; Spaventi, Radan

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 18 (2010), 17; 6559-6568

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
macrolide; quinolone; antibacterial activity; resistance

Sažetak
Four macrolides—6-O-methyl-8a-aza-8a- homoerythromycin, clarithromycin, azithromycin and azithromycin 11, 12-cyclic carbonate, have been selected for the construction of a series of new quinolone derivatives. The quinolone moiety is connected to the macrolide scaffold via a diaminoaklyl 400-O-propionyl ester chain of varying length. At the terminus the linker is attached via one of the nitrogen atoms in the linker at C(6) or C(7) of the quinolone. Many of compounds described, particularly clarithromycin derivative 37, and azithromycin derivatives 48 and 55, exhibited excellent antibacterial activity against a wide range of clinically relevant macrolide-resistant organisms, with profiles superior to that of telithromycin, an enhanced spectrum ketolide.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)

Ustanove:
Fidelta d.o.o.

Profili:

Avatar Url Hana Čipčić Paljetak (autor)

Avatar Url Andreja Fajdetić (autor)

Avatar Url Gorjana Lazarevski (autor)

Avatar Url Vitomir Šunjić (autor)

Avatar Url Vesna Eraković Haber (autor)

Avatar Url Vlado Štimac (autor)

Avatar Url Sulejman Alihodžić (autor)

Avatar Url Stjepan Mutak (autor)

Avatar Url Nataša Maršić (autor)

Avatar Url Radan Spaventi (autor)

Avatar Url Miljenko Dumić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com www.sciencedirect.com

Citiraj ovu publikaciju:

Fajdetić, Andreja; Čipčić Paljetak, Hana; Lazarevski, Gorjana; Hutinec, Anton; Alihodžić, Sulejman; Ðerek, Marko; Štimac, Vlado; Andreotti, Danielle; Šunjić, Vitomir; Berge, John et al.
400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens // Bioorganic & medicinal chemistry, 18 (2010), 17; 6559-6568 doi:10.1016/j.bmc.2010.06.049 (međunarodna recenzija, članak, znanstveni)
Fajdetić, A., Čipčić Paljetak, H., Lazarevski, G., Hutinec, A., Alihodžić, S., Ðerek, M., Štimac, V., Andreotti, D., Šunjić, V. & Berge, J. (2010) 400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens. Bioorganic & medicinal chemistry, 18 (17), 6559-6568 doi:10.1016/j.bmc.2010.06.049.
@article{article, author = {Fajdeti\'{c}, Andreja and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Lazarevski, Gorjana and Hutinec, Anton and Alihod\v{z}i\'{c}, Sulejman and \DHerek, Marko and \v{S}timac, Vlado and Andreotti, Danielle and \v{S}unji\'{c}, Vitomir and Berge, John and Mutak, Stjepan and Dumi\'{c}, Miljenko and Lociuro, Sergio and Holmes, David and Mar\v{s}i\'{c}, Nata\v{s}a and Erakovi\'{c} Haber, Vesna and Spaventi, Radan}, year = {2010}, pages = {6559-6568}, DOI = {10.1016/j.bmc.2010.06.049}, keywords = {macrolide, quinolone, antibacterial activity, resistance}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2010.06.049}, volume = {18}, number = {17}, issn = {0968-0896}, title = {400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens}, keyword = {macrolide, quinolone, antibacterial activity, resistance} }
@article{article, author = {Fajdeti\'{c}, Andreja and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Lazarevski, Gorjana and Hutinec, Anton and Alihod\v{z}i\'{c}, Sulejman and \DHerek, Marko and \v{S}timac, Vlado and Andreotti, Danielle and \v{S}unji\'{c}, Vitomir and Berge, John and Mutak, Stjepan and Dumi\'{c}, Miljenko and Lociuro, Sergio and Holmes, David and Mar\v{s}i\'{c}, Nata\v{s}a and Erakovi\'{c} Haber, Vesna and Spaventi, Radan}, year = {2010}, pages = {6559-6568}, DOI = {10.1016/j.bmc.2010.06.049}, keywords = {macrolide, quinolone, antibacterial activity, resistance}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2010.06.049}, volume = {18}, number = {17}, issn = {0968-0896}, title = {400-O-(x-Quinolylamino-alkylamino)propionyl derivatives of selected macrolides with the activity against the key erythromycin resistant respiratory pathogens}, keyword = {macrolide, quinolone, antibacterial activity, resistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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