Naslov
Fetal cerebrovascular response to chronic hypoxia

Autori
Jugović, Domagoj ; Laurini, Ricardo ; Judaš, Miloš ; Arbeille, Philippe ; Kurjak, Asim ; Salihagić, Aida

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Ultrasound in Obstetrics and Gynecology / Campbell, Stuart - Oxford : Wiley-Blackwell, 2000

Skup
10th World Congress on Ultrasound in Obstetrics and Gynecology

Mjesto i datum
Zagreb, Hrvatska, 04.10.2000. - 07.10.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
fetal hypoxia; growth-retarded fetus; Doppler

Sažetak
Objective: To study the cerebral and umbilical hemodynamics changes in hypoxic and growth-retarded fetuses. To determine if at long term, fetal brain hyperperfusion with loss of cerebral vascular flow velocity variability is associated with brain damage and poor fetal outcome. Methods: The fetal blood flow redistribution was assessed by using Doppler cerebral-umbilical ratio in 8 growth-retarded fetuses, mainly every day. The evolution of the fetal hemodynamics was interpreted according to the clinical, anatomical and histological data. Results: All 8 fetuses had poor fetal outcome including fetal death (n=5). Fetal blood flow redistribution with brain hyperperfusion was detected in all fetuses during the whole period of observation. The early phase of fetal deterioration was characterized by the development of oligohydramnios and the disappearance of the cerebral flow velocity variability. During the later phase of deterioration, fetal heart rate decelerations and the increase of cerebral vascular resistance with reduction of brain perfusion were detected. Histological study of the brains showed hypoxic lesions. Conclusion: The loss of variability of the cerebral resistance index, in the cases of absent umbilical end diastolic flow, and the loss of variability of the cerebral-umbilical ratio in the other cases, identifies the beginning of the period of very high risk for the fetus. Such a pattern may be considered as a predictor of brain lesion and poor fetal outcome. These results also indicate the existence of two phases in the fetal cerebrovascular response to chronic hypoxia.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA