Naslov
Brain Toxicokinetics of Prometryne in Mice

Autori
Đikić, Domagoj ; Sajli, Lana ; Benković, Vesna ; Horvat Knežević, Anica ; Brozović, Gordana ; Lisičić, Duje ; Mojsović, Ana ; Oršolić, Nada

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 61 (2010), 1; 19-26

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
blood; herbicide; nervous system; toxicity; triazine

Sažetak
Prometryne is a methylthio-s-triazine herbicide. Signifi cant trace amounts are found in the environment, mainly in water, soil, and food plants. The aim of this study was to establish brain and blood prometryne levels after single oral dose (1 g kg-1) in adult male and female mice. Prometryne was measured using the GC/MS assay at 1, 2, 4, 8, and 24 h after prometryne administration. Peak brain and blood prometryne values were observed 1 h after administration and they decreased in a time-dependent manner. Male mice had consistently higher brain and blood prometryne levels than female mice. The observed prometryne kinetics was similar to that reported for the structurally related herbicide atrazine.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

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