Naslov
Expression of MAGE-1, -2 and -3 genes in primary and metastatic lesions of human malignant melanomas

Autori
Juretić, Antonio ; Knežević, Fabijan ; Spagnoli, G.C. ; Jürgens-Göbel, J. ; Šamija, Mirko ; Herceg, Tonko ; Šeparović, Viktor ; Eljuga, Damir. ; Turić, Marko ; Heberer, M.

Izvornik
Croatian medical journal (0353-9504) 37 (1996), 2; 119-122

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
MAGE-1 ; -2 and -3 genes ; human malignant melanomas

Sažetak
Analysis of the expression of MAGE-1, -2 and -3 genes in melanoma tissue samples. MAGE-1, - 2 and -3 genes encode human melanoma antigens recognized by syngeneic cytotoxic lymphocytes. A reverse transcription-polymerase chain reaction (RT-PCR) was used to analyze the expression of MAGE-1, -2 and -3 genes in 15 melanoma samples at various stages of progress. The highest occurrence of gene expression was found in MAGE-1 (8/15, 53%), while MAGE-2 was expressed in 3 (20%), and MAGE-3 in 4 tumors (27%). In two samples, concomitant expression of MAGE-1 and MAGE-3 were found. Concomitant expressions of MAGE-1 and MAGE-3 genes on the one hand, and of MAGE-2 and MAGE-3 genes on the other, were observed in only one case each. Our results on MAGE-1 gene expression are similar to those found in previous research, whereas the frequencies of MAGE-2 and MAGE-3 genes are lower than the published data.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA