Naslov
Continuous wound infusion of levobupivacaine provides effective analgesia after colorectal surgery

Autori
Marić, Stela ; Štefančić, Ljilja ; Krleža Supić, Dubravka ; Vrdoljak, Danko ; Zdravčević Šakić, Kata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
The abstracts of the 5th World Congress — World Institute of Pain ; u: Pain Practise 9 (2009) (S1), 1-168 ; Poster Presentation B / - , 2009, 148-148

Skup
World Congress — World Institute of Pain (5 ; 2009)

Mjesto i datum
Sjedinjene Američke Države, 13.03.2009. - 16.03.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
levobupivacaine; wound infiltration; colorectal surgery

Sažetak
Blockade of nociceptive afferents by the use of continuous wound infusion with local anesthetics may be beneficial in a postoperative pain management after colorectal surgery. The role of continuous wound infusion of levobupivacaine for pain relief and postoperative recovery was evaluated in a randomized, double-blinded, placebo-controlled trial. Fifty patients were included in the randomized, double-blinded, placebo-controlled trial. Elective abdominal colorectal surgery was performed through midline laparotomy. At the end of surgery two multiorifice 20-gauge epidural catheters were placed suprafascial. Patients were divided in two equal groups. Group L received through the each catheter 0.25% levobupivacaine with 4 ml bolus followed by an infusion of 4 ml/h during 48 h and Group S received 0.9% NaCl at the same protocol. Simultaneously, all patients received intravenous diclofenac 75 mg every 12 h for 48 h and patient-controlled analgesia with intravenous morphine. The safety and efficacy of the technique were investigated, postoperative visual analogue pain scores and morphine requirements at 6, 12, 24 and 48 h postoperatively. Satisfactory analgesia was achieved in both groups. Levobupivacaine infusion significantly reduced morphine consumption during the first 48 h in Group L (11.160 mg +/- 5.031) in comparison to Group S (58.280 mg +/-4.364) (P < 0.001). Nausea and vomiting were less present in Group L. No side effects were observed. Postoperative pain control with continuous suprafascial wound infusion of 0.25% levobupivacaine and intravenous diclofenac after elective colorectal surgery provides effective analgesia, decreases opioid requirements and reduces postoperative nausea and vomiting.

Izvorni jezik
Engleski

Napomena
DOI: 10.1111/j.1533-2500.2009.00267.x

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