Naslov
Parallel Microwave Synthesis of 2-Styrylquinazolin-4(3H)-ones in a High-Throughput Platform Using HPLC/GC Vials as Reaction Vessels

Autori
Baghbanzadeh, Mostafa ; Molnar, Maja ; Damm, Markus ; Reidlinger, Claudia ; Dabiri, Minoo ; Kappe, C. Oliver

Izvornik
Journal of combinatorial chemistry (1520-4766) 11 (2009), 4; 676-684

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
parallel microwave synthesis; 2-styrylquinazolin-4(3H)-ones; high-throughput platform

Sažetak
The application of a high-throughput reaction platform for performing parallel microwave synthesis in sealed HPLC/GC vials contained in a strongly microwave-absorbing silicon carbide plate is described. The use of aluminum crimp caps with PTFE coated silicone septa in combination with an appropriate plate sealing mechanism allows processing of reaction volumes from 0.5-1.5 mL at temperatures of ∼250 °C and pressures of up to ∼20 bar. A library of 39 2-styrylquinazolin-4(3H)-one derivatives was prepared in a two-step/ one-pot parallel fashion involving the initial three-component condensation of four anthranilic acids with acetic anhydride and ammonium acetate at 250 °C for 30 min. This was followed by catalyst-free condensation of the resulting 2-methylquinazolinones with a selection of 15 aromatic aldehydes. Compared to singlemode sequential microwave synthesis, the overall processing times for library synthesis could be significantly reduced.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA