Pregled bibliografske jedinice broj: 472301
HLA Class II Risk allelles in Croatian patients with pemphigus
HLA Class II Risk allelles in Croatian patients with pemphigus // abstracts of the 7th International Congress on Autoimmunity
Ljubljana, Slovenija, 2010. str. 24-24 (predavanje, međunarodna recenzija, sažetak, stručni)
CROSBI ID: 472301 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
HLA Class II Risk allelles in Croatian patients with pemphigus
Autori
Marinović, Branka ; Lipozenčić, Jasna ; Đogić, Vesna ; Lakoš Jukić, Ines
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni
Izvornik
Abstracts of the 7th International Congress on Autoimmunity
/ - , 2010, 24-24
Skup
International Congress on Autoimmunity (7 ; 2010)
Mjesto i datum
Ljubljana, Slovenija, 05.05.2010. - 09.05.2010
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
HLA class II risk alleles; pemphigus vulgaris and folliaceus
Sažetak
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune blistering diseases caused by autoantibodies against keratinocyte adhesion molecules desmoglein 3 and 1 in PV patients and against desmoglein 1 only in PF patients. It is widely accepted that PV and PF are HLA associated diseases. The aim of the study was to identify the risk HLA class II alleles and haplotypes in patients with PV and PF in Croatia. During last 24 months a study of HLA genotyping in 16 patients with PV and 3 patients with PF was performed and results were compared with control group of 190 unrelated healthy blood donors at Croatian institute of transfusion medicine. HLA typing was performed using high resolution PCR-SSP method (Olerup-SSP, Saltsjöbaden, Sweden). Allele frequencies and probable haplotype associations were estimated by ARLEQIN v. 2000. In our results we observed high frequency of DRB1*0402 (AF 0.343) , DQB1*0302 (AF 0.343) and DQA1*030101 (AF 0.343). Frequency of these alleles is significanty higher than in control group (AF 0.018 ; 0.061 ; 0.061 respectively). Frequency of associated haplotype DRB1*0402-DQA1*030101- DQB1*0302 is 0.343 vs. 0.020 in control group. HLA genotyping was perfomed in only 3 PF patients as PF is much less frequent compared with PV. This number is not sufficient for statistical analysis, but in available results it is remarkable that HLA genotypes are completely different fom those in PV patients. Our results are in concordance with data available in the literature and are additional support to the hypothesis of association of HLA-DRB1*0402 in Caucasian PV patients.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
108-0000000-0105 - Autoimune bulozne dermatoze u Republici Hrvatskoj (Marinović, Branka, MZOS ) ( CroRIS)
214-2180056-0052 - Primarni kožni limfomi u Hrvatskoj (Čeović, Romana, MZOS ) ( CroRIS)
218-0000000-3657 - Maligni epidermalni kožni tumori u Hrvatskoj (Lipozenčić, Jasna, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb,
Akademija medicinskih znanosti