Naslov
Functional plasticity and robustness are essential characteristics of biological systems : lessons learned from KLRG1-deficient mice

Autori
Jonjić, Stipan

Izvornik
European journal of immunology (0014-2980) 40 (2010), 5; 1241-1243

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, komentar, znanstveni

Ključne riječi
KLRG1 deficient mice; NK cells; T cells

Sažetak
Killer cell lectin-like receptor G1 (KLRG1) receptor is considered to be a marker of terminally differentiated NK and T cells and is strongly induced by viral and other infections. KLRG1 is a C-type lectin-like inhibitory receptor, which interacts with members of the cadherin family of molecules leading to the inhibition of T- and NK-cell function. A study in this issue of the European Journal of Immunology addresses the role of KLRG1 in the maturation and differentiation of NK and T cells in vivo. Using KLRG1-deficient mice generated by homologous recombination, the study reveals that KLRG1 is dispensable for NK- and CD8+ T-cell differentiation and function in vivo. This interesting finding is discussed in this Commentary in light of the plasticity and robustness of immune response mechanisms

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA