Pregled bibliografske jedinice broj: 47110
Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres
Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres // Bioorganic & medicinal chemistry letters, 9 (1999), 3027-3030 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 47110 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Stereoselective synthesis of non symmetric dihydroxyethylene dipeptide isosteres
Autori
Benedetti, Fabio ; Magnan, Monica ; Miertus Stanislav ; Norbedo, Stefano ; Parat, Dijana ; Tossi, Alessandro
Izvornik
Bioorganic & medicinal chemistry letters (0960-894X) 9
(1999);
3027-3030
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
HIV protease inhibitors; isosteres; diols
Sažetak
(1R, 2R, 3S, 4S)-4-Amino-3-hydroxy-1,2-epoxybutanes, accessible in four steps from L-aminoesters, react regio- and stereoselectively with diethyl aluminum cyanide to give (1R, 2S, 3S, 4S)-4-amino-2,3-dihydroxynitriles. Hydrolysis yields hydroxylactones equivalent to 2,3-dihydroxy-4-aminoacids. The sequence provides a novel approach to dihydroxyethylene isosteres potentially useful for new HIV-protease inhibitors.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
