Naslov
Interaction of DBTAA derivatives with DNA / RNA and antiproliferative effects on human cell lines

Autori
Radić Stojković, Marijana ; Piantanida, Ivo ; Kralj, Marijeta ; Marjanović, Marko ; Pawlica, Dariusz ; Eilmes, Julita

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXI. Hrvatski skup kemičara i kemijskih inženjera – Knjiga sažetaka / Novak, Predrag ; Pičuljan, Katarina ; Smolec, Sonja - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2009, 99-99

ISBN
978-953-6894-38-3

Skup
XXI. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Trogir, Hrvatska, 19.04.2009. - 22.04.2009

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
DBTAA derivatives; DNA/RNA polynucleotides; intercalation; antiproliferative effect

Sažetak
Previous reports from our laboratory have described the binding properties of a series of dibenzotetraaza[14]annulenes (DBTAA) derivatives 1, 2 (Scheme 1). Scheme 1. Previously studied dibenzotetraaza[14]annulenes (DBTAA) derivatives 1, 2. We now report the binding activity of a new series of DBTAA derivatives studied by electronic absorption, circular dichroism and fluorescence spectroscopy, as well as by thermal melting experiments. The intensive hypochromic and batochromic effect in UV/Vis titrations, high affinity, strong thermal stabilisation of both, DNA and RNA, similar ICD spectra upon DNA and RNA addition strongly support the intercalation between polynucleotide base pairs as dominant mode of binding for all studied compounds. Antiproliferative effect of studied compounds on human tumor and normal cell lines was consistent with the strength of observed interactions with DNA/RNA, thus implying that interactions with cellular DNA and/or RNA are the most likely targets within the cell.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

POVEZANOST RADA