Naslov
Antiaggressive effects of a potential antidepressant dihydroergosine in two animal models of aggressiveness: Possible involvement of GABA and serotonin (5-HT)

Autori
Manev, Hari ; Peričić, Danka ; Muck-Šeler, Dorotea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Neuroscience Vol. 22 / Book of Abstracts / - , 1987, 362-362

Skup
Second World Congress of Neuroscience (IBRO)

Mjesto i datum
Budimpešta, Mađarska, 16.08.1987. - 21.08.1987

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ergot alkaloid dihydroergosine; Tests for aggressiveness; Rats; Mice; GABA; 5-HT

Sažetak
The administration of the ergot alkaloid dihydroergosine (DHESN, 50 mg/kg i.p.) inhibited the mouse-killing behavior of isolated male rats. This effect of DHESN lasted for 24 hr. When an additional injection of DHESN was given to mouse-killer rats 6 days following the first, the mouse-killing behavior was again inhibited. The effect of the second drug injection also persisted for 24 hr and was accompanied by an increased concentration of 5-HT in the raphe nuclei and hypothalamus and by a decreased concentration of GABA in the olfactory bulbs. DHESN also inhibited aggressiveness in isolated mice. These results, showing the antiaggressive effects of DHESN, support our previous suggestion that DHESN might presumably be a new antidepressant, and suggest that besides the serotoninergic, the GABA-ergic system might also be involved in the modification of behavior induced by this drug.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA