Naslov
Aseptic Meningitis, Sensorineural Hearing Loss and Vestibulopathy Induced by Simultaneous Use of Ranitidine, Ibuprofen and Ciprofloxacin

Autori
Sepčić, Juraj ; Bučuk, Mira ; Perković, Olivio ; Šepić-Grahovac, Dubravka ; Trošelj-Vukić, Biserka ; Poljak, Ivica ; Crnić-Martinvić, Marija ; Turel, Iztok ; Ristić, Smiljana ; Sepčić, Kristina

Izvornik
Collegium antropologicum (0350-6134) 34 (2010), 3; 1101-1104

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prethodno priopćenje, znanstveni

Ključne riječi
ranitidine; ibuprofen; ciprofloxacin; drug interactions; aseptic meningitis; deafness

Sažetak
We report clinically rare and serious adverse reactions that occurred after the co administration of ranitidine, ibuprofen and ciprofloxacin: completely reversible aseptic meningitis and irreversible bilateral sensorineural hearing loss, tinnitus, and vestibulopathy. Recurrent urinary inflammations treated with antibacterial, classic familial migraine, and allergy to trimethoprim-sulfamethoxazole and chromium were favourable predisposing factors for the adverse event in this patient. A close chronological relation between administration of drugs (especially ibuprofen) and adverse reactions was noted. No evidence of infection ant/or autoimmune disease was found. The mechanism of these serious events may be explained as a hypersensitive reaction affecting the meninges and, partially, cochlea.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita, Farmacija

POVEZANOST RADA