Pregled bibliografske jedinice broj: 468456
Mathematical Modelling of DNA Replication in UV-Irradiated Bacteria
Mathematical Modelling of DNA Replication in UV-Irradiated Bacteria // Studia Biophysica, 102 (1984), 2; 97-106 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 468456 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Mathematical Modelling of DNA Replication in UV-Irradiated Bacteria
Autori
Jeričević, Željko ; Trinajstić, Nenad ; Petranović, Dragutin ; Trgovčević, Željko
Izvornik
Studia Biophysica (0081-6337) 102
(1984), 2;
97-106
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
DNA Replication ; Pyrimidine Dimers ; Repair ; UV ; Modeling
Sažetak
A mathematical model of semi-conservative DNA replication in UV-irradiated bacteria has been developed, based on the Poisson distribution of the dimers through bacterial population, uniform distribution of dimers in the chromosone, and the assumption that a pyrimidine dimer is a complete block to DNA synthesis. The model is numerically evaluated by digital simulation, using the Monte Carlo method.Compared with experimental work on DNA synthesis in UV-irradiated bacteria, the results strongly suggest that the pyrimidine dimer is not an absolute block to DNA synthesis in the absence of repair.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Željko Trgovčević
(autor)
Nenad Trinajstić
(autor)
Željko Jeričević
(autor)
Dragutin Petranović
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
